ReviewCurrent opinion in structural biology2010
Unlocking the eukaryotic membrane protein structural proteome.
Review in Current opinion in structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Large-scale identification of membrane proteins with properties favorable for crystallization.Protein science : a publication of the Protein Society · 2015Article
- Revealing the Mechanisms of Protein Disorder and N-Glycosylation in CD44-Hyaluronan Binding Using Molecular Simulation.Frontiers in immunology · 2015Review
- Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.Molecular pharmaceutics · 2014Article
- Small, synthetic, GC-rich mRNA stem-loop modules 5' proximal to the AUG start-codon predictably tune gene expression in yeast.Microbial cell factories · 2013Article
- Multicolour fluorescence-detection size-exclusion chromatography for structural genomics of membrane multiprotein complexes.PloS one · 2013Article
- Expression, purification and low-resolution structure of human vitamin C transporter SVCT1 (SLC23A1).PloS one · 2013Article
- Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.PloS one · 2012Article
- The Protein Structure Initiative: achievements and visions for the future.F1000 biology reports · 2012Article
- Crystallization chaperone strategies for membrane proteins.Methods (San Diego, Calif.) · 2011Review
- Computational approaches to selecting and optimising targets for structural biology.Methods (San Diego, Calif.) · 2011Article
- Frog oocytes to unveil the structure and supramolecular organization of human transport proteins.PloS one · 2011Article
- Protein Crystallography from the Perspective of Technology Developments.Crystallography reviewsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most of the 231 unique membrane protein structures (as of 3/2010) are of bacterial membrane proteins (MPs) expressed in bacteria, or eukaryotic MPs from natural sources. However eukaryotic membrane proteins, especially those with more than three membrane crossings rarely succumb to any suitable expression in bacterial cells. They typically require expression in eukaryotic cells that can provide appropriate endoplasmic reticulum, chaperones, targeting and post-translational processing. In evidence, only approximately 20 eukaryotic MP structures have resulted from heterologous expression. This is required for a general approach to target particular human or pathogen membrane proteins of importance to human health. The first of these appeared in 2005. Our review addresses the special issues that pertain to the expression of eukaryotic and human membrane proteins, and recent advances in the tool kit for crystallization and structure determination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.