ArticleAnnals of the New York Academy of Sciences2010
Reproductive aging in invertebrate genetic models.
Article in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Axolotls retain fertility throughout lifespan.BMC biology · 2026Article
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- Male aging in germ cells: What are we inheriting?Genetics and molecular biology · 2025Article
- Morphology and Morphometry of the Reproductive Tract of the Cotton Boll Weevil after Prolonged Feeding on Alternative Diets.Insects · 2023Article
- Insulin signaling in the long-lived reproductive caste of ants.Science (New York, N.Y.) · 2022Article
- Effects of temperature on life-history traits of the newly invasive fall armyworm,Ecology and evolution · 2021Article
- Review
- Understanding Reproductive Aging in Wildlife to Improve Animal Conservation and Human Reproductive Health.Frontiers in cell and developmental biology · 2021Review
- Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: theGenes & nutrition · 2019Review
- Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell Lifespan.Developmental cell · 2018Article
- Sexual attractiveness and reproductive performance in ageing females of a coccoid insect.Biology letters · 2018Article
- Article
- Parental age influences developmental stability of the progeny in Drosophila.Proceedings. Biological sciences · 2015Article
- Review
- Article
- Effects of diet and host access on fecundity and lifespan in two fruit fly species with different life history patterns.Physiological entomology · 2013Article
- Aging studies in Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age.Age (Dordrecht, Netherlands) · 2012Article
- Healthy aging - insights from Drosophila.Frontiers in physiology · 2012Article
- Reproductive ageing: Of worms and women.Nature · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of reproductive aging and the relationship between reproduction and lifespan. Both animals show progressive decline in egg production beginning at early middle age, caused in part by reduction in germline stem cell proliferation as well as in survival of developing eggs. Molecular genetic analysis reveals that insulin and TGF-beta signaling are regulators of germline stem cell maintenance and proliferation during aging. Furthermore, the lifespan of both C. elegans and D. melanogaster appears to be regulated by signaling that depends on the presence of germline stem cells in the adult gonad. These invertebrate models provide powerful tools to dissect conserved causes of reproductive aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.