ReviewThe Journal of comparative neurology2010
Central respiratory chemoreception.
Review in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
125 citing papers in PubMed, 244 citations in OpenAlex.
- Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge.PloS one · 2020Trial
- Review
- GABAergic Inhibition from the Nucleus Tractus Solitarius to Ventrolateral Medulla Phox2b Neurons Modulates Central Respiratory Chemoreflex and Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- Hemoglobin mass and plasma volume responses are not different between lowlanders and Tibetan highlanders during early acclimatization to 4300 m.European journal of applied physiology · 2026Article
- Construction and validation of a nomogram to predict sequential oxygen therapy following extubation from invasive mechanical ventilation in patients undergoing coronary artery bypass grafting: a retrospective study.BMC research notes · 2026Article
- Prediction value of respiratory permutation entropy for hemodynamic instability events in critically ill patients with sepsis.BMC infectious diseases · 2025Article
- Characteristics of a revised quick sequential organ failure assessment score (RqSOFA) to predict in-hospital mortality of patients visiting the emergency department via ambulance: an observational cohort study.Internal and emergency medicine · 2025Observational
- EEG-Metabolic Coupling and Time Limit at V˙OJournal of functional morphology and kinesiology · 2025Article
- A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Intrinsic responses to hypoxia and hypercapnia of neurons in the cardiorespiratory center of the ventral medulla of newborn rats.Pflugers Archiv : European journal of physiology · 2025Article
- Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Respiratory neuropathology in spinocerebellar ataxia type 7.JCI insight · 2024Article
- Breath-holding as model for the evaluation of EEG signal during respiratory distress.European journal of applied physiology · 2024Review
- The Coding Logic of Interoception.Annual review of physiology · 2024Review
- Respiratory pathology in the TDP-43 transgenic mouse model of amyotrophic lateral sclerosis.Frontiers in physiology · 2024Article
- Tropine exacerbates the ventilatory depressant actions of fentanyl in freely-moving rats.Frontiers in pharmacology · 2024Article
- Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents.Scientific reports · 2023Article
- Whole-brain analysis of CObioRxiv : the preprint server for biology · 2023Article
- Maturational effect of leptin on COPediatric research · 2023Article
- Hypercapnic signaling influences hypoxic signaling in the control of breathing in C57BL6 mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to changes in brain PCO(2) or pH and contribute to the stimulation of breathing elicited by hypercapnia or metabolic acidosis. CO(2) most likely works by lowering pH. The pertinent proton receptors have not been identified and may be ion channels. CRCs are probably neurons but may also include acid-sensitive glia and vascular cells that communicate with neurons via paracrine mechanisms. Retrotrapezoid nucleus (RTN) neurons are the most completely characterized CRCs. Their high sensitivity to CO(2) in vivo presumably relies on their intrinsic acid sensitivity, excitatory inputs from the carotid bodies and brain regions such as raphe and hypothalamus, and facilitating influences from neighboring astrocytes. RTN neurons are necessary for the respiratory network to respond to CO(2) during the perinatal period and under anesthesia. In conscious adults, RTN neurons contribute to an unknown degree to the pH-dependent regulation of breathing rate, inspiratory, and expiratory activity. The abnormal prenatal development of RTN neurons probably contributes to the congenital central hypoventilation syndrome. Other CRCs presumably exist, but the supportive evidence is less complete. The proposed locations of these CRCs are the medullary raphe, the nucleus tractus solitarius, the ventrolateral medulla, the fastigial nucleus, and the hypothalamus. Several wake-promoting systems (serotonergic and catecholaminergic neurons, orexinergic neurons) are also putative CRCs. Their contribution to central respiratory chemoreception may be behavior dependent or vary according to the state of vigilance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.