ArticleMovement disorders : official journal of the Movement Disorder Society2010
Restless legs syndrome and Parkinson's disease in men.
Article in Movement disorders : official journal of the Movement Disorder Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Smoking and risk of restless leg syndrome: a systematic review, meta-analysis, and Mendelian randomisation.Journal of global health · 2026Pooled it
- Prospective study of restless legs syndrome and risk of depression in women.American journal of epidemiology · 2012Pooled it
- Risk of Parkinson Disease Among Patients With Restless Leg Syndrome.JAMA network open · 2025Article
- Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.Journal of Parkinson's disease · 2022Article
- Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Leg restlessness preceding the onset of motor symptoms of Parkinson disease: A case series of 5 patients.Medicine · 2019Article
- Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study.PLoS medicine · 2018Article
- Restless Legs Syndrome and Parkinson Disease: A Causal Relationship Between the Two Disorders?Frontiers in neurology · 2018Review
- Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Article
- Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis.Neuropsychiatric disease and treatment · 2017Article
- Nerve Decompression and Restless Legs Syndrome: A Retrospective Analysis.Frontiers in neurology · 2017Article
- Implications of nocturnal symptoms towards the early diagnosis of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Prospective study of obesity, hypertension, high cholesterol, and risk of restless legs syndrome.Movement disorders : official journal of the Movement Disorder Society · 2014Article
- Article
- Article
- Circadian and sleep disorders in Parkinson's disease.Experimental neurology · 2013Review
- Strategies for the treatment of restless legs syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We examined whether men with restless legs syndrome (RLS) have a higher prevalence of Parkinson's disease (PD) among 23,119 US participants of the Health Professional Follow-up Study who were free of diabetes and arthritis. RLS was assessed using a set of standardized questions recommended by the International RLS Study Group. PD cases were identified by self-reported questionnaires and confirmed by review of medical records. Compared to men without RLS, multivariate-adjusted odds ratios for PD were 1.1 (95% confidence interval: 0.4, 3.0) for men with RLS symptoms 5-14 times per month and 3.09 (95% confidence interval: 1.5, 6.2; P trend = 0.003) for those with symptoms 15 times or more per month, after adjusting for age, smoking, use of antidepressant, and other covariates. In conclusion, men with RLS are more likely to have concurrent PD. Prospective studies are warranted to clarify the temporal relationship between RLS and PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.