ArticleMolecular imaging and biology2011
In vitro evaluation of magnetic resonance imaging contrast agents for labeling human liver cells: implications for clinical translation.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Implementation of sodium alginate-FeScientific reports · 2022Article
- Iron Oxide Nanoparticles in Bioimaging - An Immune Perspective.Frontiers in immunology · 2021Review
- Magnetic cell labeling of primary and stem cell-derived pig hepatocytes for MRI-based cell tracking of hepatocyte transplantation.PloS one · 2015Article
- Molecular magnetic resonance imaging of brain-immune interactions.Frontiers in cellular neuroscience · 2014Review
- Article
- Cell tracking and the development of cell-based therapies: a view from the Cardiovascular Cell Therapy Research Network.JACC. Cardiovascular imaging · 2012Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMagnetic resonance imaging (MRI) is a promising approach for non-invasive monitoring after liver cell transplantation. We compared in vitro labeling of human liver cells with nano-sized (SPIO) and micron-sized iron oxide particles (MPIO). PROCEDURES: The cellular iron load was quantified and phantom studies were performed using 3.0-T MRI. Transferrin receptor and ferritin gene expression, reactive oxygen species (ROS) formation, transaminase leakage, and urea synthesis were investigated over 6 days.
resultsIncubation with MPIO produced stronger signal extinctions in MRI at similar iron loads within shorter labeling time. MPIO had no negative effects on the cellular iron homeostasis or cell performance, whereas SPIO caused temporary ROS formation and non-physiologic activation of the iron metabolic pathway.
conclusionsOur findings suggest that MPIO are suited for clinical translation of strategies for cellular imaging with MRI. Attention should be paid to iron release and oxidative stress caused by biodegradable contrast agents.
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