ArticleDeutsches Arzteblatt international2010
Dextromethorphan withdrawal and dependence syndrome.
Article in Deutsches Arzteblatt international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Focus on Over-the-Counter Drugs' Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants.Frontiers in psychiatry · 2021Pooled it
- Demographic characteristics and psychosocial backgrounds of patients with dextromethorphan overdose in Japan: A multicenter prospective observational study.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Clinical Characteristics of Over-The-Counter Drug Misusers in Psychiatric Practice in Japan: Comparison Between Codeine Misusers and Dextromethorphan Misusers.Neuropsychopharmacology reports · 2026Article
- Prospective multicenter study of the epidemiological features of emergency patients with overdose of over-the-counter drugs in Japan.PCN reports : psychiatry and clinical neurosciences · 2024Article
- High doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report.World journal of clinical cases · 2023Article
- Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry.Forensic toxicology · 2022Article
- Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring.Journal of biomedical science · 2015Article
- Cough: neurophysiology, methods of research, pharmacological therapy and phonoaudiology.International archives of otorhinolaryngology · 2012Review
- Effects of Dextromethorphan on Depressive-and Cognitive-Associated Behaviors: A Sexually Dimorphic Study.Basic and clinical neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe N-methyl-D-aspartate (NMDA) antagonist dextromethorphan has been available in pharmacies without a prescription since 1954 as an antitussive agent. There is an alarming increase in reports of its abuse. Dextromethorphan is avidly taken, mainly by young people, as a psychoactive drug. The currently available data yield incomplete information about the extent of the problem and its significance for addiction medicine in Germany. CASE PRESENTATION AND COURSE: We report the case of a 44-year-old man who became dependent on dextromethorphan through years of abuse, buying the substance for himself without a prescription in German pharmacies. He told us he had taken it regularly for six years. He had become dependent on dextromethorphan, ultimately taking it in a dose of 1800 mg daily. This led him to overt neglect of his work and leisure activities. A urine sample taken on admission to the hospital was found to contain dextromethorphan. During inpatient detoxification, he developed an vegetative withdrawal syndrome consisting of craving, diaphoresis, nausea, hypertension, and tachycardia. He was treated on our ward for three weeks, and a stay in a residential detoxification facility was planned thereafter.
conclusionDextromethorphan is a psychotropic substance that carries a potential for abuse and dependence. On the basis of the currently available data, its reclassification as a prescription drug should be considered.
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Registered trials
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