ArticleBritish journal of cancer2010
Prolactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case-control study from Poland.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Inclusion of Plasma Prolactin Levels in Current Risk Prediction Models of Premenopausal and Postmenopausal Breast Cancer.JNCI cancer spectrum · 2018Article
- Determinants of prolactin in postmenopausal Chinese women in Singapore.Cancer causes & control : CCC · 2018Article
- The Evaluation of Serum Biomarkers for Non-small Cell Lung Cancer (NSCLC) Diagnosis.Frontiers in physiology · 2018Article
- Article
- Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study.Breast cancer research : BCR · 2015Article
- Circulating sex hormones and terminal duct lobular unit involution of the normal breast.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Breast cancer risk in older women: results from the NIH-AARP Diet and Health Study.Cancer causes & control : CCC · 2014Article
- Prolactin receptor expression and breast cancer: relationships with tumor characteristics among pre- and post-menopausal women in a population-based case-control study from Poland.Hormones & cancer · 2014Article
- Circulating prolactin levels and risk of epithelial ovarian cancer.Cancer causes & control : CCC · 2013Article
- Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop.Journal of the National Cancer Institute · 2013Review
- Prolactin promotes hepatocellular carcinoma through Janus kinase 2.World journal of surgery · 2012Article
- Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland.Breast cancer research : BCR · 2011Article
- Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies.BMC cancer · 2010Article
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundPrevious prospective studies have found an association between prolactin (PRL) levels and increased risk of breast cancer. Using data from a population-based breast cancer case-control study conducted in two cities in Poland (2000-2003), we examined the association of PRL levels with breast cancer risk factors among controls and with tumour characteristics among the cases.
methodsWe analysed PRL serum levels among 773 controls without breast cancer matched on age and residence to 776 invasive breast cancer cases with available pretreatment serum. Tumours were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis. Breast cancer risk factors, assessed by interview, were related to serum PRL levels among controls using analysis of variance. Mean serum PRL levels by tumour characteristics are reported. These associations also were evaluated using polytomous logistic regression.
resultsProlactin levels were associated with nulliparity in premenopausal (P=0.05) but not in postmenopausal women. Associations in postmenopausal women included an inverse association with increasing body mass index (P=0.0008) and direct association with use of recent/current hormone therapy (P=0.0006). In case-only analyses, higher PRL levels were more strongly associated with lobular compared with ductal carcinoma among postmenopausal women (P=0.02). Levels were not different by tumour size, grade, node involvement or oestrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2 status.
conclusionsOur analysis demonstrates that PRL levels are higher among premenopausal nulliparous as compared with parous women. Among postmenopausal women, levels were higher among hormone users and lower among obese women. These results may have value in understanding the mechanisms underlying several breast cancer risk factor associations.
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