ReviewNature reviews. Nephrology2010
B cells and transplantation tolerance.
Review in Nature reviews. Nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft.Kidney international · 2015Pooled it
- Blocking plasma cell fate enhances antigen-specific presentation by B cells to boost anti-tumor immunity.Nature communications · 2025Article
- A Lesson of Immunosuppression in Renal Transplant: Retreat or Hold?The Yale journal of biology and medicine · 2023Observational
- Article
- High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection.International journal of molecular sciences · 2020Article
- Desensitization and treatment with APRIL/BLyS blockade in rodent kidney transplant model.PloS one · 2019Article
- B-Cell Activating Factor Predicts Acute Rejection Risk in Kidney Transplant Recipients: A 6-Month Follow-Up Study.Frontiers in immunology · 2019Article
- Observational
- Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients.PloS one · 2016Article
- Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance.Transplantation · 2015Article
- New immunosuppressive agents in pediatric transplantation.Clinics (Sao Paulo, Brazil) · 2014Review
- Biologic agents in islet transplantation.Current diabetes reports · 2013Review
- Elevated pretransplantation soluble BAFF is associated with an increased risk of acute antibody-mediated rejection.Transplantation · 2013Article
- Nuclear antigens and auto/alloantibody responses: friend or foe in transplant immunology.Clinical & developmental immunology · 2013Review
- Pretransplant infusion of donor B cells enhances donor-specific skin allograft survival.PloS one · 2013Article
- Revascularization of transplanted pancreatic islets and role of the transplantation site.Clinical & developmental immunology · 2013Review
- Elevated serum levels of B-cell activating factor in pediatric renal transplant patients.Pediatric nephrology (Berlin, Germany) · 2012Article
- B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naïve B cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses.Diabetes · 2012Article
- Biomarkers of tolerance: searching for the hidden phenotype.Kidney international supplements · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transplantation tolerance is a state of immune unresponsiveness (or benign responsiveness) to the presence of specific, nonself antigens in the absence of chronic immunosuppressive therapy. Renal transplant tolerance remains a desired yet generally unattained goal that would enable transplantation to be performed without the risk of graft rejection or the need for broadly immunosuppressive drugs, which can have toxic effects. Studies published in the past few years have provided evidence that B cells have an important role in both graft rejection and transplantation tolerance. Indeed, antibody-dependent and antibody-independent functions of B cells account for both tolerogenic and rejection-promoting immune responses in transplant recipients. This Review comprises a discussion of the mechanisms involved in the induction of B-cell tolerance and a survey of current and emerging therapies that target the effects of B cells in transplant recipients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.