ArticleLearning & memory (Cold Spring Harbor, N.Y.)2010
The sensitivity of memory consolidation and reconsolidation to inhibitors of protein synthesis and kinases: computational analysis.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Article
- Transcriptional Changes Fade Prior to Long-Term Memory for Sensitization of thebioRxiv : the preprint server for biology · 2025Article
- Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2.PLoS computational biology · 2022Article
- Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation.Frontiers in computational neuroscience · 2020Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking.PLoS computational biology · 2018Article
- Transcriptional correlates of memory maintenance following long-term sensitization ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- A Model of Synaptic Reconsolidation.Frontiers in neuroscience · 2016Article
- Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Atypical PKCs in memory maintenance: the roles of feedback and redundancy.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.Breast cancer research : BCR · 2015Article
- Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model.PLoS computational biology · 2012Article
- The requirement for enhanced CREB1 expression in consolidation of long-term synaptic facilitation and long-term excitability in sensory neurons of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Maintenance of memory by negative feedback of synaptic protein elimination: modeling KIBRA-PKMζ dynamics in LTP.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Memory consolidation and reconsolidation require kinase activation and protein synthesis. Blocking either process during or shortly after training or recall disrupts memory stabilization, which suggests the existence of a critical time window during which these processes are necessary. Using a computational model of kinase synthesis and activation, we investigated the ways in which the dynamics of molecular positive-feedback loops may contribute to the time window for memory stabilization and memory maintenance. In the models, training triggered a transition in the amount of kinase between two stable states, which represented consolidation. Simulating protein synthesis inhibition (PSI) from before to 40 min after training blocked or delayed consolidation. Beyond 40 min, substantial (>95%) PSI had little effect despite the fact that the elevated amount of kinase was maintained by increased protein synthesis. However, PSI made established memories labile to perturbations. Simulations of kinase inhibition produced similar results. In addition, similar properties were found in several other models that also included positive-feedback loops. Even though our models are based on simplifications of the actual mechanisms of molecular consolidation, they illustrate the practical difficulty of empirically measuring "time windows" for consolidation. This is particularly true when consolidation and reconsolidation of memory depends, in part, on the dynamics of molecular positive-feedback loops.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.