ArticleBMJ (Clinical research ed.)2010
Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study.
Article in BMJ (Clinical research ed.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Migraine and risk of all-cause mortality and specific cause mortality: a systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects.BMJ open · 2018Pooled it
- Migraine and mortality: a systematic review and meta-analysis.Cephalalgia : an international journal of headache · 2011Pooled it
- Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.Cephalalgia : an international journal of headache · 2013Trial
- Cardiovascular disease in women: traditional and sex-specific risk factors.European heart journal · 2026Review
- Menopause Hormone Therapy in Women With Cardiovascular Risk Factors or Established Ischemic Heart Disease: A Joint FIGO and WHF Position Paper.Global heart · 2026Review
- Prevalence of migraine in Iceland.The journal of headache and pain · 2025Article
- Review
- Migraine and increased cardiovascular disease risk: interaction with traditional risk factors and lifestyle factors.The journal of headache and pain · 2025Article
- Progesterone receptors regulate susceptibility to spreading depression.Experimental neurology · 2025Article
- Migraine in men.The journal of headache and pain · 2025Review
- Cardiovascular Risk Scores and Migraine Status.JAMA network open · 2024Article
- Sex-Specific Association of Cardiovascular Risk Factors With Migraine: The Population-Based Rotterdam Study.Neurology · 2024Article
- Cohort profile: migraine exposures and cardiovascular health in Hong Kong Chinese women (MECH-HK).BMJ open · 2024Article
- Triptan use in elderly over 65 years and the risk of hospitalization for serious vascular events.The journal of headache and pain · 2024Article
- A higher probability of subsequent stroke and ischemic heart disease in migraine patients: a longitudinal follow-up study in Korea.The journal of headache and pain · 2023Article
- Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine.HGG advances · 2023Article
- Estimation of migraine prevalence considering active and inactive states across different age groups.The journal of headache and pain · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo estimate whether migraine in mid-life is associated with mortality from cardiovascular disease, other causes, and all causes.
designPopulation based cohort study.
settingReykjavik, Iceland.
participants18,725 men and women, born 1907-35 and living in Reykjavik and adjacent communities.
main outcome measuresMortality from cardiovascular disease, non-cardiovascular disease, and all causes. Questionnaires and clinical measures were obtained in mid-life (mean age 53, range 33-81) in the Reykjavik Study (1967-91). Headache was classified as migraine without aura, migraine with aura, or non-migraine headache. Median follow-up was 25.9 years (0.1-40.2 years), with 470,990 person years and 10,358 deaths: 4323 from cardiovascular disease and 6035 from other causes. We used Cox regression to estimate risk of death in those with migraine compared with others, after adjusting for baseline risk factors.
resultsPeople with migraine with aura were at increased risk of all cause mortality (adjusted (for sex and multivariables) hazard ratio 1.21, 95% confidence interval 1.12 to 1.30) and mortality from cardiovascular disease (1.27, 1.13 to 1.43) compared with people with no headache, while those with migraine without aura and non-migraine headache were not. Further examination of mortality from cardiovascular disease shows that people with migraine with aura were at increased risk of mortality from coronary heart disease (1.28, 1.11 to 1.49) and stroke (1.40, 1.10 to 1.78). Women with migraine with aura were also at increased risk of mortality from non-cardiovascular disease (1.19, 1.06 to 1.35).
conclusionsMigraine with aura is an independent risk factor for cardiovascular and all cause mortality in men and women. The risk of mortality from coronary heart disease and stroke mortality is modestly increased in people with migraine, particularly those with aura.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.