ArticleBMJ (Clinical research ed.)2010
Migraine and risk of haemorrhagic stroke in women: prospective cohort study.
Article in BMJ (Clinical research ed.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 7 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Migraine and pregnancy-related headaches as a risk factor for cardiovascular and cerebrovascular events in pregnancy: a systematic review and meta-analysis of over 94 million pregnancies.The journal of headache and pain · 2025Pooled it
- Genetically proxied liability to migraine and risk of intracranial aneurysm and subarachnoid hemorrhage.Headache · 2025Pooled it
- Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects.BMJ open · 2018Pooled it
- Migraine and the risk of stroke: an updated meta-analysis of prospective cohort studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Pooled it
- Guideline
- Migraine and mortality: a systematic review and meta-analysis.Cephalalgia : an international journal of headache · 2011Pooled it
- Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses in the Women's Health Study.Cephalalgia : an international journal of headache · 2011Trial
- Article
- Migraine is associated with a higher risk of ischemic and hemorrhagic stroke: an analysis of theFrontiers in pain research (Lausanne, Switzerland) · 2025Article
- Migraine and Stroke: A Scoping Review.Journal of clinical medicine · 2024Article
- Stroke Risk Reduction in Migraine Patients Using Propranolol: Evidence from Two Large-Scale Real-World Data Analyses.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Review
- Hypertension and Migraine: Time to Revisit the Evidence.Current pain and headache reports · 2021Review
- Observational
- Migraine and risk of stroke.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Migraine prevalence in patients with unruptured intracranial aneurysms: A case-control study.Brain and behavior · 2017Article
- Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The potential impact of primary headache disorders on stroke risk.The journal of headache and pain · 2016Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the association between migraine and migraine aura status with risk of haemorrhagic stroke.
designProspective cohort study.
settingWomen's Health Study, United States.
participants27,860 women aged >or=45 who were free from stroke or other major disease at baseline and had provided information on self reported migraine, aura status, and lipid values.
main outcome measuresTime to first haemorrhagic stroke and subtypes of haemorrhagic stroke.
resultsAt baseline, 5130 (18%) women reported any history of migraine; of the 3612 with active migraine (migraine in the previous year), 1435 (40%) described having aura. During a mean of 13.6 years of follow-up, 85 haemorrhagic strokes were confirmed after review of medical records. Compared with women without a history of migraine, there was no increased risk of haemorrhagic stroke in those who reported any history of migraine (adjusted hazard ratio 0.98, 95% confidence interval 0.56 to 1.71, P=0.93). In contrast, risk was increased in women with active migraine with aura (2.25, 1.11 to 4.54, P=0.024). The age adjusted increased risk was stronger for intracerebral haemorrhage (2.78, 1.09 to 7.07, P=0.032) and for fatal events (3.56, 1.23 to 10.31, P=0.02). Four additional haemorrhagic stroke events were attributable to migraine with aura per 10 000 women per year. Women who reported active migraine without aura had no increased risk for haemorrhagic stroke.
conclusionMigraine with aura might, in addition to ischaemic events, also be a risk factor for haemorrhagic stroke. The relatively low number of events and attributable risk should caution against definitive conclusions and call for further confirmation of these observations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.