ArticleNeuroscience2010
Expression patterns of estrogen receptors in the central auditory system change in prepubertal and aged mice.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Differential expression of steroid-related genes across electrosensory brain regions in two sexually dimorphic species of electric knifefish.General and comparative endocrinology · 2024Review
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- Sex differences and the effect of female sex hormones on auditory function: a systematic review.Frontiers in human neuroscience · 2023Review
- Effects of aging on the response of single neurons to amplitude-modulated noise in primary auditory cortex of rhesus macaque.Journal of neurophysiology · 2016Article
- Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.EMBO molecular medicine · 2016Article
- The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis.Therapeutics and clinical risk management · 2016Article
- Expression of estrogen receptor α in the mouse cerebral cortex.Molecular and cellular endocrinology · 2015Article
- Sexual attractiveness of male chemicals and vocalizations in mice.Frontiers in neuroscience · 2014Review
- Estrogenic modulation of auditory processing: a vertebrate comparison.Frontiers in neuroendocrinology · 2013Review
- Estradiol selectively enhances auditory function in avian forebrain neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Tonotopic relationships reveal the charge density varies along the lateral wall of outer hair cells.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Estrogens are important in the development, maintenance and physiology of the CNS. Several studies have shown their effects on the processing of hearing in both males and females, and these effects, in part, are thought to result from regulation of the transcription of genes via their classical estrogen receptor (ER) pathway. In order to understand the spatiotemporal changes that occur with age, we have studied the expression of ERs in the central auditory pathway in prepubertal and aged CBA mice with immunohistochemistry. In prepubertal mice a clear dichotomy was noted between the expression of ERα and ERβ. ERβ-positive neurons were found in the metencephalon whereas the majority of ERα was found in mesencephalon, diencephalon or the telencephalon. In the aged animals a different pattern of ER expression was found in terms of location and overall intensity. These age-induced changes in the expression pattern were generally not uniform, suggesting that region-specific mechanisms regulate the ERs' age-related expression. Neither the prepubertal nor the aged animals showed sex differences in any auditory structure. Our results demonstrate different age-dependent spatial and temporal changes in the pattern of expression of ERα and ERβ, suggesting that each ER type may be involved in distinct roles across the central auditory pathway in different periods of maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.