ArticleRespiratory research2010
Female sex hormones mediate the allergic lung reaction by regulating the release of inflammatory mediators and the expression of lung E-selectin in rats.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Alleviation of allergic rhinitis symptoms in an animal model byFrontiers in immunology · 2026Article
- Associations of urinary organophosphate esters metabolites with asthma and lung function in adolescents.Journal of exposure science & environmental epidemiology · 2024Article
- Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors.Frontiers in allergy · 2022Review
- Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease-19 (COVID-19): A scoping review.Journal of medical virology · 2021Article
- Gender Differences in Low-Molecular-Mass-Induced Acute Lung Inflammation in Mice.International journal of molecular sciences · 2021Article
- Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma.Oxidative medicine and cellular longevity · 2021Review
- Sex-Steroid Signaling in Lung Diseases and Inflammation.Advances in experimental medicine and biology · 2021Article
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- Sex Steroid Hormones and Asthma in a Nationwide Study of U.S. Adults.American journal of respiratory and critical care medicine · 2020Article
- Novel Insights on Sex-Related Differences in Asthma.Current allergy and asthma reports · 2019Review
- Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.Brain, behavior, and immunity · 2019Review
- Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study.International journal of inflammation · 2019Article
- Endocrine regulation of lung disease and inflammation.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Estrogen Modulates the Sensitivity of Lung Vagal C Fibers in Female Rats Exposed to Intermittent Hypoxia.Frontiers in physiology · 2018Article
- Bronchial hyperreactivity in perimenstrual asthma is associated with increased Th-2 response in lower airways.Journal of thoracic disease · 2017Article
- Effects of periodontitis on the development of asthma: The role of photodynamic therapy.PloS one · 2017Article
- The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin.Clinics (Sao Paulo, Brazil) · 2013Article
- The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluctuations of estradiol and progesterone levels caused by the menstrual cycle worsen asthma symptoms. Conflicting data are reported in literature regarding pro and anti-inflammatory properties of estradiol and progesterone.
methodsFemale Wistar rats were ovalbumin (OVA) sensitized 1 day after resection of the ovaries (OVx). Control group consisted of sensitized-rats with intact ovaries (Sham-OVx). Allergic challenge was performed by aerosol (OVA 1%, 15 min) two weeks later. Twenty four hours after challenge, BAL, bone marrow and total blood cells were counted. Lung tissues were used as explants, for expontaneous cytokine secretion in vitro or for immunostaining of E-selectin.
resultsWe observed an exacerbated cell recruitment into the lungs of OVx rats, reduced blood leukocytes counting and increased the number of bone marrow cells. Estradiol-treated OVx allergic rats reduced, and those treated with progesterone increased, respectively, the number of cells in the BAL and bone marrow. Lungs of OVx allergic rats significantly increased the E-selectin expression, an effect prevented by estradiol but not by progesterone treatment. Systemically, estradiol treatment increased the number of peripheral blood leukocytes in OVx allergic rats when compared to non treated-OVx allergic rats. Cultured-BAL cells of OVx allergic rats released elevated amounts of LTB4 and nitrites while bone marrow cells increased the release of TNF-alpha and nitrites. Estradiol treatment of OVx allergic rats was associated with a decreased release of TNF-alpha, IL-10, LTB4 and nitrites by bone marrow cells incubates. In contrast, estradiol caused an increase in IL-10 and NO release by cultured-BAL cells. Progesterone significantly increased TNF- alpha by cultured BAL cells and bone marrow cells.
conclusionsData presented here suggest that upon hormonal oscillations the immune sensitization might trigger an allergic lung inflammation whose phenotype is under control of estradiol. Our data could contribute to the understanding of the protective role of estradiol in some cases of asthma symptoms in fertile ans post-menopausal women clinically observed.
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