ArticleMolecular microbiology2010
Temporal anatomy of an epigenetic switch in cell programming: the white-opaque transition of C. albicans.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Response ofmSphere · 2026Article
- Transcriptional control ofmBio · 2025Article
- Regulation of Ergosterol Biosynthesis in Pathogenic Fungi: Opportunities for Therapeutic Development.Microorganisms · 2025Review
- Is a Fungal Apocalypse Inevitable or Just a Hallucination? An Overview of the Antifungal Armamentarium Used in the Fight against Pathogenic Fungi.ACS medicinal chemistry letters · 2025Review
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Strain and temperature dependent aggregation ofCell surface (Amsterdam, Netherlands) · 2023Article
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- Multiple molecular events underlie stochastic switching between 2 heritable cell states in fungi.PLoS biology · 2022Article
- Role of themBio · 2021Article
- Unbelievable but True: Epigenetics and Chromatin in Fungi.Trends in genetics : TIG · 2021Review
- Transcriptional Circuits Regulating Developmental Processes inFrontiers in cellular and infection microbiology · 2020Review
- Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism.Cell host & microbe · 2019Article
- HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence.Scientific reports · 2018Article
- Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans.PLoS genetics · 2018Article
- Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs.Antimicrobial agents and chemotherapy · 2017Article
- Article
- Article
- An expanded regulatory network temporally controls Candida albicans biofilm formation.Molecular microbiology · 2015Article
- Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes.Virulence · 2015Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The human pathogen Candida albicans undergoes a well-defined switch between two distinct cell types, named 'white' and 'opaque'. White and opaque cells differ in metabolic preferences, mating behaviours, cellular morphologies and host interactions. Each cell type is stable through many generations; switching between them is rare, stochastic and occurs without any known changes in the primary sequence of the genome; thus the switch is epigenetic. The white-opaque switch is regulated by a transcriptional circuit, composed of four regulators arranged in a series of interlocking feedback loops. To understand how switching occurs, we investigated the order of regulatory changes that occur during the switch from the opaque to the white cell type. Surprisingly, changes in key transcriptional regulators occur gradually, extending over several cell divisions with little cell-to-cell variation. Additional experiments, including perturbations to regulator concentrations, refine the signature of the commitment point. Transcriptome analysis reveals that opaque cells begin to globally resemble white cells well before they irreversibly commit to switching. We propose that these characteristics of the switching process permit C. albicans to 'test the waters' before making an all-or-none decision.
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