ReviewBritish journal of pharmacology2010
New insights into the molecular mechanisms of general anaesthetics.
Review in British journal of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05315648 (The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction (ACLR): Prospective, Randomized Trial
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature.Frontiers in neuroscience · 2023Pooled it
- Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia.PloS one · 2017Trial
- Enhanced glymphatic CSF tracer influx during α2-adrenergic agonist anesthesia is independent of tracer injection duration.bioRxiv : the preprint server for biology · 2026Article
- The volatile anesthetic isoflurane causes global suppression of neuronal activity, disrupting hub neuron function inFrontiers in systems neuroscience · 2026Article
- Efficacy and safety of remimazolam vs. propofol for general anesthesia with tracheal intubation: Systematic review and meta‑analysis.Biomedical reports · 2025Article
- Xenon anaesthesia is associated with a reduction in frontal electroencephalogram peak alpha frequency.BJA open · 2024Article
- Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL).Trials · 2024Article
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone.Neuropharmacology · 2021Article
- Towards Quantum-Chemical Modeling of the Activity of Anesthetic Compounds.International journal of molecular sciences · 2021Review
- Heart rate variability-derived features based on deep neural network for distinguishing different anaesthesia states.BMC anesthesiology · 2021Article
- Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain.Scientific reports · 2020Article
- Review
- Inhibition of NR2B-containing NMDA receptors during nitrogen narcosis.Diving and hyperbaric medicine · 2019Article
- Determination of narcotic potency using a neurobehavioral assay with larval zebrafish.Neurotoxicology · 2019Article
- Lasting effects of general anesthetics on the brain in the young and elderly: "mixed picture" of neurotoxicity, neuroprotection and cognitive impairment.Journal of anesthesia · 2019Review
- Anesthetic activity and the electrostatic potential (revisited).Journal of molecular modeling · 2017Article
- Ketamine attenuates the glutamatergic neurotransmission in the ventral posteromedial nucleus slices of rats.BMC anesthesiology · 2017Article
- Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity.Molecules (Basel, Switzerland) · 2017Review
- Anesthesia management of cesarean section in parturient with anti-N-methyl-D-aspartate receptor encephalitis: a case report.Journal of anesthesia · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper provides new insights of how general anaesthetic research should be carried out in the future by an analysis of what we know, what we do not know and what we would like to know. I describe previous hypotheses on the mechanism of action of general anaesthetics (GAs) involving membranes and protein receptors. I provide the reasons why the GABA type A receptor, the NMDA receptor and the glycine receptor are strong candidates for the sites of action of GAs. I follow with a review on attempts to provide a mechanism of action, and how future research should be conducted with the help of physical and chemical methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.