ArticleEuropean biophysics journal : EBJ2011
Transiently crosslinked F-actin bundles.
Article in European biophysics journal : EBJ, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Theory of active self-organization of dense nematic structures in the actin cytoskeleton.eLife · 2025Article
- TMEM16A Maintains Acrosomal Integrity Through ERK1/2, RhoA, and Actin Cytoskeleton During Capacitation.International journal of molecular sciences · 2025Article
- Systematic altering of semiflexible DNA-based polymer networksNanoscale · 2023Article
- Nonlinear Microscale Mechanics of Actin Networks Governed by Coupling of Filament Crosslinking and Stabilization.Polymers · 2022Article
- Crowding tunes the organization and mechanics of actin bundles formed by crosslinking proteins.FEBS letters · 2021Article
- Detecting heterogeneity in and between breast cancer cell lines.Cancer convergence · 2020Article
- Influence of Network Topology on the Viscoelastic Properties of Dynamically Crosslinked Hydrogels.Frontiers in chemistry · 2020Article
- Actin droplet machine.Royal Society open science · 2019Article
- Computing on actin bundles network.Scientific reports · 2019Article
- Prestressed cells are prone to cytoskeleton failures under localized shear strain: an experimental demonstration on muscle precursor cells.Scientific reports · 2018Article
- Synthetic Transient Crosslinks Program the Mechanics of Soft, Biopolymer-Based Materials.Advanced materials (Deerfield Beach, Fla.) · 2018Article
- DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers.Journal of visualized experiments : JoVE · 2017Article
- Single Actin Bundle Rheology.Molecules (Basel, Switzerland) · 2017Article
- Adaptive Response of Actin Bundles under Mechanical Stress.Biophysical journal · 2017Article
- Semiflexible Biopolymers in Bundled Arrangements.Polymers · 2016Review
- Actin Mechanics and Fragmentation.The Journal of biological chemistry · 2015Review
- Article
- Mechanical detection of a long-range actin network emanating from a biomimetic cortex.Biophysical journal · 2014Article
- Elasto-plastic response of reversibly crosslinked biopolymer bundles.The European physical journal. E, Soft matter · 2014Article
- Spatio-temporal dynamics of an active, polar, viscoelastic ring.The European physical journal. E, Soft matter · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
F-actin bundles are prominent cytoskeletal structures in eukaryotes. They provide mechanical stability in stereocilia, microvilli, filopodia, stress fibers and the sperm acrosome. Bundles are typically stabilized by a wide range of specific crosslinking proteins, most of which exhibit off-rates on the order of 1s(-1). Yet F-actin bundles exhibit structural and mechanical integrity on time scales that are orders of magnitude longer. By applying large deformations to reconstituted F-actin bundles using optical tweezers, we provide direct evidence of their differential mechanical response in vitro: bundles exhibit fully reversible, elastic response on short time scales and irreversible, elasto-plastic response on time scales that are long compared to the characteristic crosslink dissociation time. Our measurements show a broad range of characteristic relaxation times for reconstituted F-actin bundles. This can be reconciled by considering that bundle relaxation behavior is also modulated by the number of filaments, crosslinking type and occupation number as well as the consideration of defects due to filament ends.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.