ReviewCerebellum (London, England)2012
Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons.
Review in Cerebellum (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Calcium channelopathies and intellectual disability: a systematic review.Orphanet journal of rare diseases · 2021Pooled it
- Multifaceted Mesodiencephalic Triangles: Insights into Hypertrophic Olivary Degeneration and Oculopalatal Tremor Pathophysiology.Cerebellum (London, England) · 2025Review
- T-type CaCell reports · 2023Article
- mGluR1 Regulates the Interspike Interval Threshold for Dendritic CaExperimental neurobiology · 2023Article
- Gating by Memory: a Theory of Learning in the Cerebellum.Cerebellum (London, England) · 2022Article
- Expression Pattern of T-Type CaCells · 2021Article
- Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis.Cerebellum (London, England) · 2020Review
- Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias.International journal of molecular sciences · 2020Review
- The Origin of Physiological Local mGluR1 Supralinear CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Two Distinct Sets of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons.Scientific reports · 2019Article
- Sub-synaptic localization of CaBrain structure & function · 2017Article
- Genetic Tracing of CaFrontiers in molecular neuroscience · 2017Article
- Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.The Journal of physiology · 2017Article
- Electrical and Ca(2+) signaling in dendritic spines of substantia nigra dopaminergic neurons.eLife · 2016Article
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
- Low threshold T-type calcium channels as targets for novel epilepsy treatments.British journal of clinical pharmacology · 2014Review
- A synaptic mechanism for network synchrony.Frontiers in cellular neuroscience · 2014Review
- Construction and identification of the pshRNA-CACNA1G-SH-SY5Ycells targeted to silence Cav3.1 mRNA expression.Biomedical reports · 2013Article
- Synaptic NMDA receptor-dependent Ca²⁺ entry drives membrane potential and Ca²⁺ oscillations in spinal ventral horn neurons.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Low threshold voltage-gated T-type calcium channels have long been implicated in the electrical excitability and calcium signaling of cerebellar Purkinje neurons although the molecular composition, localization, and modulation of T-type channels within Purkinje cells have only recently been addressed. The specific functional roles that T-type channels play in local synaptic integration within Purkinje spines are also currently being unraveled. Overall, Purkinje neurons represent a powerful model system to explore the potential roles of postsynaptic T-type channels throughout the nervous system. In this review, we present an overview of T-type calcium channel biophysical, pharmacological, and physiological characteristics that provides a foundation for understanding T-type channels within Purkinje neurons. We also describe the biophysical properties of T-type channels in context of other voltage-gated calcium channel currents found within Purkinje cells. The data thus far suggest that one specific T-type isoform, Ca(v)3.1, is highly expressed within Purkinje spines and both physically and functionally couples to mGluR1 and other effectors within putative signaling microdomains. Finally, we discuss how the selective potentiation of Ca(v)3.1 channels via activation of mGluR1 by parallel fiber inputs affects local synaptic integration and how this interaction may relate to the overall excitability of Purkinje neuron dendrites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.