ArticleMolecular imaging and biology2011
Quantification of iron-labeled cells with positive contrast in mouse brains.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Multimodal Imaging with NanoGd Reveals Spatiotemporal Features of Neuroinflammation after Experimental Stroke.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Magnetic core-shell nanowires as MRI contrast agents for cell tracking.Journal of nanobiotechnology · 2020Article
- MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation.Scientific reports · 2019Article
- Quantifying tumor associated macrophages in breast cancer: a comparison of iron and fluorine-based MRI cell tracking.Scientific reports · 2017Article
- Magnetic Nanoparticles: Material Engineering and Emerging Applications in Lithography and Biomedicine.Journal of materials science · 2016Article
- In vivo visualization of cells labeled with superparamagnetic iron oxides by a sub-millisecond gradient echo sequence.Magma (New York, N.Y.) · 2014Article
- Article
- Monitoring therapeutic effects in experimental stroke by serial USPIO-enhanced MRI.European radiology · 2013Article
- Positive contrast with therapeutic iron nanoparticles at 4.7 T.Magma (New York, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo quantify small amounts of iron-labeled cells in mouse brains with magnetic resonance imaging (MRI). PROCEDURES: Iron-labeled cells (from 500 to 7,500) were stereotaxically transplanted into the brain of living mice that were subsequently imaged with MRI at 4.7 T. We compared four quantitative methods: (1) T2 relaxometry, (2) T2* relaxometry, (3) the volume of the cloverleaf hypointense artifact generated on T2*-weighted images, and (4) the volume of the cloverleaf hyperintense artifact generated on positive contrast images.
resultsThe methods based on relaxometry, whether T2 or T2*, did not correlate with the number of injected cells. By contrast, those based on measurement of cloverleaf artifact volume, whether using negative or positive enhancement, showed a significant linear relationship for the given range of cells (R [0.92-0.95], p < 0.05).
conclusionsT2* artifact volume imaging (negative or positive) appears promising for the quantification of magnetically labeled cells following focal injection in the brain.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.