ReviewJournal of innate immunity2010
Gene-specific epigenetic regulation in serious infections with systemic inflammation.
Review in Journal of innate immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Protein modification by short-chain fatty acid metabolites in sepsis: a comprehensive review.Frontiers in immunology · 2023Review
- Impact of Inherited Genetic Variants on Critically Ill Septic Children.Pathogens (Basel, Switzerland) · 2022Review
- Epigenetic Alterations and Inflammation as Emerging Use for the Advancement of Treatment in Non-Small Cell Lung Cancer.Frontiers in immunology · 2022Review
- Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways.Antioxidants (Basel, Switzerland) · 2021Review
- Bacteria in the amniotic fluid without inflammation: early colonization vs. contamination.Journal of perinatal medicine · 2021Article
- Review
- SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.Shock (Augusta, Ga.) · 2020Article
- Sirtuins: potential therapeutic targets for regulating acute inflammatory response?Expert opinion on therapeutic targets · 2020Review
- Epigenetic and metabolic programming of innate immunity in sepsis.Innate immunity · 2019Review
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- Transcriptome Profiling of Bovine Macrophages Infected byFrontiers in immunology · 2019Article
- IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development.Cellular immunology · 2018Article
- Lactate and Immunosuppression in Sepsis.Shock (Augusta, Ga.) · 2018Review
- Emerging Evidence concerning the Role of Sirtuins in Sepsis.Critical care research and practice · 2018Review
- Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism.Frontiers in cellular neuroscience · 2018Review
- Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression.Molecular immunology · 2017Article
- Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice.Journal of leukocyte biology · 2017Article
- The bioenergetics of inflammation: insights into obesity and type 2 diabetes.European journal of clinical nutrition · 2017Review
- Protective vaccination and blood-stage malaria modify DNA methylation of gene promoters in the liver of Balb/c mice.Parasitology research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Inflammation is a fundamental biologic process that is evolutionally conserved by a germ line code. The interplay between epigenetics and environment directs the code into temporally distinct inflammatory responses, which can be acute or chronic. Here, we discuss the epigenetic processes of innate immune cells during serious infections with systemic inflammation in four stages: homeostasis, incitement, evolution, and resolution. We describe feed-forward loops of serious infections with systemic inflammation that create gene-specific silent facultative heterochromatin and active euchromatin according to gene function, and speculate on the role of epigenetics in survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.