ArticleProceedings of the National Academy of Sciences of the United States of America2010
A Trojan horse mechanism of bacterial pathogenesis against nematodes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 142 citations in OpenAlex.
- Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense.Chemistry & biodiversity · 2026Article
- Predation in microbial communities: gradients of nutritive killing.Nature reviews. Microbiology · 2026Review
- Root-knot nematode Meloidogyne incognita uses secondary-metabolite-mediated soil microbiome shifts to locate host plants.Nature plants · 2026Article
- Nematicidal indole oxazoles and chemoattractants from soil bacteria.bioRxiv : the preprint server for biology · 2026Article
- Metabolomics analysis reveals diverse nematicidal metabolites from spore-forming bacteria.AIMS microbiology · 2026Article
- Different concentrations of 2-Undecanone triggers repellent and nematicidal responses in Caenorhabditis elegans.Scientific reports · 2025Article
- Volatile Organic Compounds of Diverse Origins and Their Changes Associated With Cultivar Decay in a Fungus-Farming Termite.Environmental microbiology · 2025Article
- Behavioral adaptations ofPeerJ · 2025Review
- Modeling Host-Pathogen Interactions inInternational journal of molecular sciences · 2024Review
- Urea regulates soil nematode population by enhancing the nematode-trapping ability of nematode-trapping fungi.Scientific reports · 2024Article
- Biosynthesis of Cry5B-Loaded Sulfur Nanoparticles usingACS omega · 2024Article
- 3-(Methylthio)Propionic Acid fromInternational journal of molecular sciences · 2024Article
- Chemical basis of microbiome preference in the nematode C. elegans.Scientific reports · 2024Article
- Exploring the nematicidal mechanisms and control efficiencies of oxalic acid producingFrontiers in microbiology · 2024Article
- Antioxidant characteristics of hydrolysate from low-value sea cucumber:Food chemistry: X · 2023Article
- Profile of Prof. Ke-Qin Zhang.Science China. Life sciences · 2023Article
- Multiple Receptors Contribute to the Attractive Response of Caenorhabditis elegans to Pathogenic Bacteria.Microbiology spectrum · 2023Article
- The Fight against Plant-Parasitic Nematodes: Current Status of Bacterial and Fungal Biocontrol Agents.Pathogens (Basel, Switzerland) · 2022Review
- Secondary Metabolites from the Endoparasitic Nematophagous FungusMicroorganisms · 2022Article
- Identification of Nematicidal Metabolites fromMicroorganisms · 2022Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Understanding the mechanisms of host-pathogen interaction can provide crucial information for successfully manipulating their relationships. Because of its genetic background and practical advantages over vertebrate model systems, the nematode Caenorhabditis elegans model has become an attractive host for studying microbial pathogenesis. Here we report a "Trojan horse" mechanism of bacterial pathogenesis against nematodes. We show that the bacterium Bacillus nematocida B16 lures nematodes by emitting potent volatile organic compounds that are much more attractive to worms than those from ordinary dietary bacteria. Seventeen B. nematocida-attractant volatile organic compounds are identified, and seven are individually confirmed to lure nematodes. Once the bacteria enter the intestine of nematodes, they secrete two proteases with broad substrate ranges but preferentially target essential intestinal proteins, leading to nematode death. This Trojan horse pattern of bacterium-nematode interaction enriches our understanding of microbial pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.