ArticleThe Journal of biological chemistry2010
Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 49 citations in OpenAlex.
- Kinetic control of mammalian transcription elongation.Nature structural & molecular biology · 2026Article
- Multiple direct and indirect roles of the Paf1 complex in transcription elongation, splicing, and histone modifications.Cell reports · 2024Article
- Multiple direct and indirect roles of Paf1C in elongation, splicing, and histone post-translational modifications.bioRxiv : the preprint server for biology · 2024Article
- Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models.The Journal of clinical investigation · 2023Article
- Article
- The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans.Genes to cells : devoted to molecular & cellular mechanisms · 2022Article
- The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin.Journal of molecular biology · 2021Review
- TREND-DB-a transcriptome-wide atlas of the dynamic landscape of alternative polyadenylation.Nucleic acids research · 2021Article
- Defining the ATPome reveals cross-optimization of metabolic pathways.Nature communications · 2020Article
- Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms.Molecular and cellular biology · 2020Article
- New Roles for Canonical Transcription Factors in Repeat Expansion Diseases.Trends in genetics : TIG · 2020Review
- Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.Nature neuroscience · 2019Article
- A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma.Nature communications · 2018Article
- mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription.Cell reports · 2018Article
- Cdc73 suppresses genome instability by mediating telomere homeostasis.PLoS genetics · 2018Article
- Phyllotactic regularity requires the Paf1 complex inDevelopment (Cambridge, England) · 2017Article
- Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.Nature communications · 2017Article
- RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases.eLife · 2017Article
- Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate.Molecular cell · 2017Article
- The RNA Polymerase-Associated Factor 1 Complex Is Required for Plant Touch Responses.Journal of experimental botany · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Paf1 complex (Paf1C) affects RNA polymerase II transcription by coordinating co-transcriptional chromatin modifications and helping recruit mRNA 3' end processing factors. Paf1C cross-links to transcribed genes, but not downstream of the cleavage and polyadenylation site, suggesting that it may interact with the nascent mRNA. Paf1C purified from Saccharomyces cerevisiae binds RNA in vitro, as do the purified Leo1 and Rtf1 subunits of the complex. In vivo cross-linking and immunoprecipitation of RNA associated with Paf1C (RNA-IP) show that Leo1, but not Rtf1, is necessary for the complex to bind RNA. Cells lacking Leo1 have reduced Paf1C recruitment as well as decreased levels of histone H3 and trimethylated H3 Lys(4) within transcribed chromatin. Together, these results suggest that association of Paf1C with RNA stabilizes its localization at actively transcribed regions where it influences chromatin structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.