ReviewInternational immunology2010
Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells.
Review in International immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- The ability of memory CD8 T cell subsets to numerically and functionally recover following whole body irradiation is influenced by their history of cognate antigen exposures.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling.Frontiers in immunology · 2025Article
- A guide to adaptive immune memory.Nature reviews. Immunology · 2024Review
- Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti-Leukemia Efficacy of CAR-T Cells via SOCE-Calcineurin-NFAT and Glycolysis Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Titratable Pharmacological Regulation of CAR T Cells Using Zinc Finger-Based Transcription Factors.Cancers · 2021Article
- Review
- Recent advances and discoveries in the mechanisms and functions of CAR T cells.Nature reviews. Cancer · 2021Review
- Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy.Frontiers in immunology · 2021Review
- The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma.Cancer immunology research · 2021Article
- Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability.The Journal of clinical investigation · 2020Article
- CAR T Cells Redirected to CD44v6 Control Tumor Growth in Lung and Ovary Adenocarcinoma Bearing Mice.Frontiers in immunology · 2020Article
- The Quest for the Hippocampal Memory Engram: From Theories to Experimental Evidence.Frontiers in behavioral neuroscience · 2020Review
- Grandparental immune priming in the pipefish Syngnathus typhle.BMC evolutionary biology · 2017Article
- T Cell Receptor and Cytokine Signaling Can Function at Different Stages to Establish and Maintain Transcriptional Memory and Enable T Helper Cell Differentiation.Frontiers in immunology · 2017Review
- Bacteria-type-specific biparental immune priming in the pipefishEcology and evolution · 2016Article
- The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung.Frontiers in immunology · 2016Review
- CD8+ T cell exhaustion, suppressed gamma interferon production, and delayed memory response induced by chronic Brucella melitensis infection.Infection and immunity · 2015Article
- Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.Nature medicine · 2015Article
- Tolerance and exhaustion: defining mechanisms of T cell dysfunction.Trends in immunology · 2014Review
- Human memory T cells: generation, compartmentalization and homeostasis.Nature reviews. Immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Clonal expansion of virus-specific naive T cells during an acute viral infection results in the formation of memory CD8 T cells that provide the host with long-term protective immunity against the pathogen. Memory CD8 T cells display enhanced effector functions compared with their naive precursors, allowing them to respond more rapidly and effectively to antigen re-encounter. The enhanced functions of memory CD8 T cells are mediated by heritable changes in gene regulation. Expression of select transcription factors along with locus-specific epigenetic modifications are coupled to and are essential in the formation of memory-specific gene expression patterns. Here, we will review the changes in gene expression that accompany development of memory CD8 T cells and discuss chromatin modifications as a potential means for heritable propagation of these changes during homeostatic cell division of self-renewing memory CD8 T cells. Also, we will discuss therapies that manipulate heritable gene regulation as a potential mechanism to restore function to non-functional memory CD8 T cells to combat chronic viral infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.