ArticleJournal of the American Academy of Child and Adolescent Psychiatry2010
Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.Biological psychiatry · 2017Pooled it
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.Attention deficit and hyperactivity disorders · 2017Pooled it
- Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Pooled it
- Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients.Biological psychiatry global open science · 2026Article
- Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and theACS chemical neuroscience · 2023Article
- PsychArray-Based Genome Wide Association Study of Suicidal Deaths in India.Brain sciences · 2023Article
- Association of theAmerican journal of translational research · 2023Article
- Functional abnormality in the sensorimotor system attributed to NRXN1 variants in boys with attention deficit hyperactivity disorder.Brain imaging and behavior · 2022Article
- Hexokinase domain-containing protein-1 in metabolic diseases and beyond.Trends in endocrinology and metabolism: TEM · 2022Review
- Deep learning model reveals potential risk genes for ADHD, especially Ephrin receptor gene EPHA5.Briefings in bioinformatics · 2021Article
- A CommonGenes · 2021Article
- Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Developmental exposure to methylmercury and ADHD, a literature review of epigenetic studies.Environmental epigenetics · 2021Review
- ADHD: Current Concepts and Treatments in Children and Adolescents.Neuropediatrics · 2020Review
- STX1A gene variations contribute to the susceptibility of children attention-deficit/hyperactivity disorder: a case-control association study.European archives of psychiatry and clinical neuroscience · 2019Article
- Genetics of attention deficit hyperactivity disorder.Molecular psychiatry · 2019Review
- A case-control genome-wide association study of ADHD discovers a novel association with the tenascin R (TNR) gene.Translational psychiatry · 2018Article
- Association of Polygenic Risk for Attention-Deficit/Hyperactivity Disorder With Co-occurring Traits and Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Methylphenidate enhances neuronal differentiation and reduces proliferation concomitant to activation of Wnt signal transduction pathways.Translational psychiatry · 2018Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors at 17 institutions in 8 countries.
Funding
Abstract
objectiveAlthough twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed.
methodWe used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model.
resultsNo genome-wide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1.
conclusionsThe current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.