ArticleDevelopmental biology2010
Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype inFrontiers in cell and developmental biology · 2023Article
- Mitochondrial-Y chromosome epistasis inProceedings. Biological sciences · 2020Article
- Changes in endolysosomal organization define a pre-degenerative state in the crumbs mutant Drosophila retina.PloS one · 2019Article
- Multifunctional glial support by Semper cells in the Drosophila retina.PLoS genetics · 2017Article
- Article
- Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina.PLoS genetics · 2015Article
- Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans.PLoS genetics · 2014Article
- Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.PLoS genetics · 2014Article
- Opposite feedbacks in the Hippo pathway for growth control and neural fate.Science (New York, N.Y.) · 2013Article
- Conserved roles of ems/Emx and otd/Otx genes in olfactory and visual system development in Drosophila and mouse.Open biology · 2013Review
- Article
- Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
Orthodenticle (Otd)-related transcription factors are essential for anterior patterning and brain morphogenesis from Cnidaria to Mammals, and genetically underlie several human retinal pathologies. Despite their key developmental functions, relatively little is known regarding the molecular basis of how these factors regulate downstream effectors in a cell- or tissue-specific manner. Many invertebrate and vertebrate species encode two to three Otd proteins, whereas Drosophila encodes a single Otd protein. In the fly retina, Otd controls rhabdomere morphogenesis of all photoreceptors and regulates distinct Rhodopsin-encoding genes in a photoreceptor subtype-specific manner. Here, we performed a structure-function analysis of Otd during Drosophila eye development using in vivo rescue experiments and in vitro transcriptional regulatory assays. Our findings indicate that Otd requires at least three distinct transcriptional regulatory domains to control photoreceptor-specific rhodopsin gene expression and photoreceptor morphogenesis. Our results also uncover a previously unknown role for Otd in preventing co-expression of sensory receptors in blue vs. green-sensitive R8 photoreceptors. Sequence analysis indicates that many of the transcriptional regulatory domains identified here are conserved in multiple Diptera Otd-related proteins. Thus, these studies provide a basis for identifying shared molecular pathways involved in a wide range of developmental processes.
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