ArticleJournal of studies on alcohol and drugs2010
Do premorbid predictors of alcohol dependence also predict the failure to recover from alcoholism?
Article in Journal of studies on alcohol and drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- COVID and college: how the pandemic impacted alcohol use disorder status among students.Journal of American college health : J of ACH · 2024Article
- Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank.Alcohol, clinical & experimental research · 2024Article
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- Interest in and perceived effectiveness of contingency management among alcohol drinkers using behavioral economic purchase tasks.Experimental and clinical psychopharmacology · 2023Article
- Reduced Working Memory is Associated with Heavier Alcohol Consumption History, Role Impairment and Executive Function Difficulties.AIDS and behavior · 2021Article
- Onset Age of Substance Use and Neuropsychological Performance in Hospital Patients.Clinical neuropsychiatry · 2020Article
- History of Alcohol Consumption and HIV Status Related to Functional Connectivity Differences in the Brain During Working Memory Performance.Current HIV research · 2020Article
- A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism.Alcoholism, clinical and experimental research · 2018Article
- Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques.Alcohol (Fayetteville, N.Y.) · 2017Article
- Drinking Status Between Ages 50 and 55 for Men From the San Diego Prospective Study Who Developed DSM-IV Alcohol Abuse or Dependence in Prior Follow-Ups.Journal of studies on alcohol and drugs · 2017Article
- Reduced Social Network Drinking is Associated with Improved Response Inhibition in Women During Early Recovery from Alcohol Use Disorders: A Pilot Study.Alcoholism, clinical and experimental research · 2016Article
- Social contexts of remission from DSM-5 alcohol use disorder in a high-risk sample.Alcoholism, clinical and experimental research · 2014Article
- Seventy-five years of comorbidity research.Journal of studies on alcohol and drugs. Supplement · 2014Review
- Predictors of initial and sustained remission from alcohol use disorders: findings from the 30-year follow-up of the San Diego Prospective Study.Alcoholism, clinical and experimental research · 2013Article
- Environmental influences predominate in remission from alcohol use disorder in young adult twins.Psychological medicine · 2012Article
- X chromosome inactivation in women with alcoholism.Alcoholism, clinical and experimental research · 2012Article
- Genetics of dopamine receptors and drug addiction.Human genetics · 2012Review
- Is alcohol dependence best viewed as a chronic relapsing disorder?Addiction (Abingdon, England) · 2012Article
- Effects of premature birth on the risk for alcoholism appear to be greater in males than females.Journal of studies on alcohol and drugs · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveIn a search for viable endophenotypes of alcoholism, this longitudinal study attempted to identify premorbid predictors of alcohol dependence that also predicted the course of alcoholism.
methodThe 202 male subjects who completed a 40-year follow-up were originally selected from a Danish birth cohort (N = 9,182). Two thirds of the subjects were high-risk biological sons of treated alcoholics. A large number of measures (361) were obtained at different periods before any subject had developed an alcohol-use disorder. At age 40, a psychiatrist provided mutually exclusive lifetime diagnoses of alcohol abuse or alcohol dependence that were characterized as currently active or currently in remission according to Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, course specifiers.
resultsThe majority of subjects with a diagnosis of alcohol abuse were in remission at age 40 compared with those with a diagnosis of alcohol dependence (88% vs. 58%). Treatment did not predict remission. Fourteen of the 18 predictors of remission that also predicted dependence were submitted to an exploratory factor analysis (varimax). Two premorbid dimensions were identified: cognitive efficiency and early behavioral dyscontrol in childhood. Both factors predicted the failure to remit (low cognitive efficiency and high behavioral dyscontrol) even when lifetime alcoholism severity was controlled.
conclusionsThis 4-decade study found a striking disconnect between measures that predicted alcohol dependence and measures that predicted remission from alcohol dependence. Reduced cognitive efficiency and increased behavioral dyscontrol may be basic to gaining a fuller understanding of the etiology of alcoholism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.