ArticleBMC neuroscience2010
Epilepsy is related to theta band brain connectivity and network topology in brain tumor patients.
Article in BMC neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Brain network disintegration as a final common pathway for delirium: a systematic review and qualitative meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Pooled it
- Graph Theory-Based Electroencephalographic Connectivity and Its Association with Ketogenic Diet Effectiveness in Epileptic Children.Nutrients · 2021Trial
- Altered Network Topology in Patients with Primary Brain Tumors After Fractionated Radiotherapy.Brain connectivity · 2017Trial
- Magnetoencephalography Reveals a Widespread Increase in Network Connectivity in Idiopathic/Genetic Generalized Epilepsy.PloS one · 2015Trial
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- GLUT1-DS Brain Organoids Exhibit Increased Sensitivity to Metabolic and Pharmacological Induction of Epileptiform Activity.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Brain regions associated with frequent occurrences of seizures related to low-grade gliomas: a voxel-level evidence.Frontiers in human neuroscience · 2026Article
- Functional connectivity in electroencephalography of brain tumor patients in status epilepticus: a retrospective evaluation of prognostic value.Quantitative imaging in medicine and surgery · 2026Article
- Research progress in glioma-related epilepsy (Review).Biomedical reports · 2025Article
- Machine learning on interictal intracranial EEG predicts surgical outcome in drug resistant epilepsy.NPJ digital medicine · 2025Article
- Presurgical structural connectivity predicts postsurgical cognitive impairment in glioma patients.Brain communications · 2025Article
- Dynamic evolution of frontal-temporal network connectivity in temporal lobe epilepsy: A magnetoencephalography study.Human brain mapping · 2024Article
- Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life.Journal of cancer survivorship : research and practice · 2024Article
- Efficacy and Safety of Pulse Intravenous Methylprednisolone in Pediatric Epileptic Encephalopathies: Timing and Networks Consideration.Journal of clinical medicine · 2024Article
- Comparison of Resting-State EEG Network Analyses With and Without Parallel MRI in Genetic Generalized Epilepsy.Brain topography · 2023Article
- Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.Scientific reports · 2023Article
- Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities.Frontiers in human neuroscience · 2023Review
- The role of epidemic spreading in seizure dynamics and epilepsy surgery.Network neuroscience (Cambridge, Mass.) · 2023Article
- Dynamic effect of electromagnetic induction on epileptic waveform.BMC neuroscience · 2022Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth epilepsy patients and brain tumor patients show altered functional connectivity and less optimal brain network topology when compared to healthy controls, particularly in the theta band. Furthermore, the duration and characteristics of epilepsy may also influence functional interactions in brain networks. However, the specific features of connectivity and networks in tumor-related epilepsy have not been investigated yet. We hypothesize that epilepsy characteristics are related to (theta band) connectivity and network architecture in operated glioma patients suffering from epileptic seizures. Included patients participated in a clinical study investigating the effect of levetiracetam monotherapy on seizure frequency in glioma patients, and were assessed at two time points: directly after neurosurgery (t1), and six months later (t2). At these time points, magnetoencephalography (MEG) was recorded and information regarding clinical status and epilepsy history was collected. Functional connectivity was calculated in six frequency bands, as were a number of network measures such as normalized clustering coefficient and path length.
resultsAt the two time points, MEG registrations were performed in respectively 17 and 12 patients. No changes in connectivity or network topology occurred over time. Increased theta band connectivity at t1 and t2 was related to a higher total number of seizures. Furthermore, higher number of seizures was related to a less optimal, more random brain network topology. Other factors were not significantly related to functional connectivity or network topology.
conclusionsThese results indicate that (pathologically) increased theta band connectivity is related to a higher number of epileptic seizures in brain tumor patients, suggesting that theta band connectivity changes are a hallmark of tumor-related epilepsy. Furthermore, a more random brain network topology is related to greater vulnerability to seizures. Thus, functional connectivity and brain network architecture may prove to be important parameters of tumor-related epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.