ArticleGenes, brain, and behavior2011
Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice.
Article in Genes, brain, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- The Healthy Brains and Behavior Study: objectives, design, recruitment, and population coverage.International journal of methods in psychiatric research · 2013Trial
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Environmental Exposure to the Common Trunk of Mammalian Appeasing Pheromone Modulates Social Behavior and Reduces Fight Wounds in Male Mice.Animals : an open access journal from MDPI · 2025Article
- Thirty Mouse Strain Survey of Voluntary Physical Activity and Energy Expenditure: Influence of Strain, Sex and Day-Night Variation.Frontiers in neuroscience · 2020Article
- Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen.Molecular neurobiology · 2017Article
- Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver.The Journal of biological chemistry · 2017Article
- Article
- Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.Molecular psychiatry · 2014Article
- Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes.Frontiers in neuroscience · 2014Article
- Neurogenetics of aggressive behavior: studies in rodents.Current topics in behavioral neurosciences · 2014Review
- Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuse.Behavior genetics · 2011Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Aggressive behaviors are disabling, treatment refractory, and sometimes lethal symptoms of several neuropsychiatric disorders. However, currently available treatments for patients are inadequate, and the underlying genetics and neurobiology of aggression is only beginning to be elucidated. Inbred mouse strains are useful for identifying genomic regions, and ultimately the relevant gene variants (alleles) in these regions, that affect mammalian aggressive behaviors, which, in turn, may help to identify neurobiological pathways that mediate aggression. The BALB/cJ inbred mouse strain exhibits relatively high levels of intermale aggressive behaviors and shows multiple brain and behavioral phenotypes relevant to neuropsychiatric syndromes associated with aggression. The A/J strain shows very low levels of aggression. We hypothesized that a cross between BALB/cJ and A/J inbred strains would reveal genomic loci that influence the tendency to initiate intermale aggressive behavior. To identify such loci, we conducted a genomewide scan in an F2 population of 660 male mice bred from BALB/cJ and A/J inbred mouse strains. Three significant loci on chromosomes 5, 10 and 15 that influence aggression were identified. The chromosome 5 and 15 loci are completely novel, and the chromosome 10 locus overlaps an aggression locus mapped in our previous study that used NZB/B1NJ and A/J as progenitor strains. Haplotype analysis of BALB/cJ, NZB/B1NJ and A/J strains showed three positional candidate genes in the chromosome 10 locus. Future studies involving fine genetic mapping of these loci as well as additional candidate gene analysis may lead to an improved biological understanding of mammalian aggressive behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.