ReviewActa physiologica (Oxford, England)2011
Erythrocytes as controllers of perfusion distribution in the microvasculature of skeletal muscle.
Review in Acta physiologica (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men.Journal of the International Society of Sports Nutrition · 2016Trial
- Examining Erythrocytes as Potential Blood Biomarkers for Autism Spectrum Disorder: Their Relationship to Symptom Severity and Adaptive Behavior.Biomedicines · 2024Article
- Druggable Targets in Cyclic Nucleotide Signaling Pathways in Apicomplexan Parasites and Kinetoplastids against Disabling Protozoan Diseases in Humans.International journal of molecular sciences · 2019Review
- Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1.Scientific reports · 2018Article
- Purinergic control of red blood cell metabolism: novel strategies to improve red cell storage quality.Blood transfusion = Trasfusione del sangue · 2017Review
- Accelerating metabolism and transmembrane cation flux by distorting red blood cells.Science advances · 2017Article
- Red cell distribution width in anemic patients undergoing transcatheter aortic valve implantation.World journal of cardiology · 2016Article
- Article
- Blood cells: an historical account of the roles of purinergic signalling.Purinergic signalling · 2015Review
- Red cell physiology and signaling relevant to the critical care setting.Current opinion in pediatrics · 2015Review
- A Putative Non-Canonical Ras-Like GTPase from P. falciparum: Chemical Properties and Characterization of the Protein.PloS one · 2015Article
- Mechanical response of red blood cells entering a constriction.Biomicrofluidics · 2014Article
- New insights into carbonic anhydrase inhibition, vasodilation, and treatment of hypertensive-related diseases.Current hypertension reports · 2014Review
- Oral adenosine-5'-triphosphate (ATP) administration increases blood flow following exercise in animals and humans.Journal of the International Society of Sports Nutrition · 2014Article
- Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes.Biochimica et biophysica acta · 2013Article
- Effects of oral adenosine-5'-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men.Nutrition & metabolism · 2013Article
- Purinergic signalling and diabetes.Purinergic signalling · 2013Review
- Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxation.International journal of physiology, pathophysiology and pharmacology · 2013Article
- Physiological mechanisms for the modulation of pannexin 1 channel activity.The Journal of physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In 1929, August Krogh identified the matching of oxygen (O(2)) supply with demand in skeletal muscle as a fundamental physiological process. In the intervening decades, much research has been focused on elucidating the mechanisms by which this important process occurs. For any control system to be effective, there must be a means by which the need is determined and a mechanism by which that information is coupled to an appropriate response. The focus of this review was to highlight current research in support of the hypothesis that the mobile erythrocyte, when exposed to reduced O(2) tension, releases ATP in a controlled manner. This ATP interacts with purinergic receptors on the endothelium producing both local and conducted vasodilation enabling the erythrocyte to distribute perfusion to precisely match O(2) delivery with need in skeletal muscle. If this is an important mechanism for normal physiological control of microvascular perfusion, defects in this process would be anticipated to have pathophysiological consequences. Individuals with either type 2 diabetes (DM2) or pre-diabetes have microvascular dysfunction that contributes to morbidity and mortality. DM2 erythrocytes and erythrocytes incubated with insulin at levels similar to those seen in pre-diabetes fail to release ATP in response to reduced O(2) tension. Knowledge of the components of the signal transduction pathway for low O(2) -induced ATP release suggest novel therapeutic approaches to ameliorating this defect. Although the erythrocyte may be but one component of the complex O(2) delivery process, it appears to play an important role in distributing oxygen within the microvasculature.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.