ArticleThe Journal of infectious diseases2010
Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 74 citations in OpenAlex.
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- Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry.Cell reports methods · 2026Article
- ZIP8 loss impairs macrophage-mediated phagolysosomal removal of bacteria and is overcome by butyrate supplementation.Communications biology · 2026Article
- Influence of Zinc onJournal of fungi (Basel, Switzerland) · 2024Article
- Utilization of amSphere · 2024Article
- How metals fuel fungal virulence, yet promote anti-fungal immunity.Disease models & mechanisms · 2023Review
- Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?Infection and immunity · 2023Review
- Immunity to fungi in the lung.Seminars in immunology · 2023Review
- Mac1-Dependent Copper Sensing PromotesmBio · 2022Article
- Estimation of Serum Levels of Heavy Metals in Patients with Chronic Invasive Fungal Rhinosinusitis Before the COVID-19 Era: A Pilot Study.Turkish archives of otorhinolaryngology · 2022Article
- Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants.BMC microbiology · 2021Article
- A metabolic inhibitor arms macrophages to kill intracellular fungal pathogens by manipulating zinc homeostasis.The Journal of clinical investigation · 2021Article
- Nutritional immunity: targeting fungal zinc homeostasis.Heliyon · 2021Review
- Metallothionein 1: A New Spotlight on Inflammatory Diseases.Frontiers in immunology · 2021Review
- The Zinc Nutritional Immunity ofFrontiers in immunology · 2021Article
- Insights IntoFrontiers in cellular and infection microbiology · 2020Article
- The Role of Zinc in Gliotoxin Biosynthesis ofInternational journal of molecular sciences · 2019Article
- Sensing the heat and the host: Virulence determinants ofVirulence · 2019Review
- Review
- Metals in fungal virulence.FEMS microbiology reviews · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The fungal pathogen Histoplasma capsulatum evades the innate and adaptive immune responses and thrives within resting macrophages. Cytokines that induce antimicrobial activity, such as granulocyte macrophage colony-stimulating factor (GM-CSF), inhibit H. capsulatum growth in macrophages. Conversely, interleukin 4 inhibits the killing of intracellular pathogens. Using inductively coupled plasma mass spectrometry, we examined alterations in the metal homeostasis of murine H. capsulatum-infected macrophages that were exposed to activating cytokines. Decreases in the levels of iron (Fe(2+) and Fe(3+)) and zinc (Zn(2+)) were observed in infected, GM-CSF-treated macrophages compared with those in infected controls. Interleukin 4 reversed the antifungal activity of GM-CSF-activated macrophages and was associated with increased intracellular Zn(2+) levels. Chelation of Zn(2+) inhibited yeast replication in both the absence of macrophages and the presence of macrophages. Treatment of cells with GM-CSF altered the host Zn(2+) binding species profile. These results establish that Zn(2+) deprivation may be a host defense mechanism utilized by macrophages.
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Registered trials
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