ArticlePest management science2010
Mode of action of methoprene in affecting female reproduction in the African malaria mosquito, Anopheles gambiae.
Article in Pest management science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Immune-reproductive cross talk in mosquitoes: molecular pathways and energy homeostasis.Parasites & vectors · 2026Review
- Roles of Vitellogenin and Its Receptor Genes in Female Reproduction of the Cigarette Beetle,Insects · 2025Article
- The midgut epithelium of mosquitoes adjusts cell proliferation and endoreplication to respond to physiological challenges.BMC biology · 2024Article
- The impact of non-lethal doses of pyriproxyfen on male and femaleFrontiers in insect science · 2024Article
- Long-Chain Molecules with Agro-Bioactivities and Their Applications.Molecules (Basel, Switzerland) · 2023Review
- Midgut Epithelial Dynamics Are Central to Mosquitoes' Physiology and Fitness, and to the Transmission of Vector-Borne Disease.Frontiers in cellular and infection microbiology · 2021Article
- Molecular action of pyriproxyfen: Role of the Methoprene-tolerant protein in the pyriproxyfen-induced sterilization of adult female mosquitoes.PLoS neglected tropical diseases · 2020Article
- 20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae.mSphere · 2020Article
- Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium.PLoS neglected tropical diseases · 2020Article
- The male mosquito contribution towards malaria transmission: Mating influences the Anopheles female midgut transcriptome and increases female susceptibility to human malaria parasites.PLoS pathogens · 2019Article
- Article
- Changes in Larval Mosquito Microbiota Reveal Non-target Effects of Insecticide Treatments in Hurricane-Created Habitats.Microbial ecology · 2018Article
- Analysis of natural female post-mating responses of Anopheles gambiae and Anopheles coluzzii unravels similarities and differences in their reproductive ecology.Scientific reports · 2018Article
- Anopheline Reproductive Biology: Impacts on Vectorial Capacity and Potential Avenues for Malaria Control.Cold Spring Harbor perspectives in medicine · 2017Review
- Anopheles gambiae hemocytes exhibit transient states of activation.Developmental and comparative immunology · 2016Article
- A comparative analysis of reproductive biology of insect vectors of human disease.Current opinion in insect science · 2015Article
- Mosquito biology. Evolution of sexual traits influencing vectorial capacity in anopheline mosquitoes.Science (New York, N.Y.) · 2015Article
- Pyriproxyfen for mosquito control: female sterilization or horizontal transfer to oviposition substrates by Anopheles gambiae sensu stricto and Culex quinquefasciatus.Parasites & vectors · 2014Article
- Mating activates the heme peroxidase HPX15 in the sperm storage organ to ensure fertility in Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles.The Journal of experimental biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOne of the most studied actions of juvenile hormone (JH) is its ability to modulate ecdysteroid signaling during insect development and metamorphosis. Previous studies in mosquitoes showed that 20-hydroxyecdysone (20E) regulates vitellogenin synthesis. However, the action of JH and its mimics, e.g. methoprene, on female reproduction of mosquitoes remains unknown.
resultsHere, a major malaria vector, Anopheles gambiae Giles, was used as a model insect to study the action of methoprene on female reproduction. Ecdysteroid titers and expression profiles of ecdysone-regulated genes were determined before and after a blood meal. An ecdysteroid peak was detected at 12 h post blood meal (PBM). The maximum expression of ecdysone-regulated genes, such as ecdysone receptor (EcR), hormone receptor 3 (HR3) and vitellogenin (Vg) gene, coincided with the ecdysteroid peak. Interestingly, topical application of methoprene at 6 h PBM delayed ovarian development and egg maturation by suppressing the expression of ecdysone-regulated genes in female mosquitoes.
conclusionThe data suggest that ecdysteroid titers are correlated with Vg synthesis, and methoprene affects vitellogenesis by modulating ecdysteroid action in A. gambiae.
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