ArticleJournal of biomedical materials research. Part A2010
Characterization of the chemotactic and mitogenic response of SMCs to PDGF-BB and FGF-2 in fibrin hydrogels.
Article in Journal of biomedical materials research. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- miR-567 indicates atherosclerosis development and regulates inflammation, phenotype switch, proliferation, and migration of platelet-derived growth factor (PDGF)-BB-induced vascular smooth muscle cells (VSMCs) via CSF1R.Journal of molecular histology · 2026Article
- Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture in high-level athletes.Regenerative therapy · 2025Article
- Injectable composite microspheres/hydrogel membranes for Achilles tendon regeneration.Materials today. Bio · 2025Article
- A Promising Candidate in Tendon Healing Events-PDGF-BB.Biomolecules · 2022Review
- Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation.Chinese medicine · 2021Article
- Cellular Self-Assembly with Microsphere Incorporation for Growth Factor Delivery Within Engineered Vascular Tissue Rings.Tissue engineering. Part A · 2017Article
- Smooth Muscle Stiffness Sensitivity is Driven by Soluble and Insoluble ECM Chemistry.Cellular and molecular bioengineering · 2015Article
- Biomimetic-engineered poly (ethylene glycol) hydrogel for smooth muscle cell migration.Tissue engineering. Part A · 2014Article
- p53 Down regulates PDGF-induced formation of circular dorsal ruffles in rat aortic smooth muscle cells.PloS one · 2014Article
- Proangiogenic hydrogels within macroporous scaffolds enhance islet engraftment in an extrahepatic site.Tissue engineering. Part A · 2013Article
- Angiogenic endothelial cell invasion into fibrin is stimulated by proliferating smooth muscle cells.Microvascular research · 2013Article
- The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis.Oncology letters · 2012Article
- PDGF: the nuts and bolts of signalling toolbox.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The delivery of growth factors to cellularize biocompatible scaffolds like fibrin is a commonly used strategy in tissue engineering. We characterized smooth muscle cells (SMC) proliferation and chemotaxis in response to PDGF-BB and FGF-2, alone and in combination, in 2D culture and in 3D fibrin hydrogels. While both growth factors induced an equipotent mitogenic response in 2D culture, only FGF-2 was significantly mitogenic for SMCs in 3D culture. Only PDGF-BB was significantly chemotactic in a modified Boyden chamber assay. In a 3D assay of matrix invasion, both growth factors induced an invasive response into the fibrin hydrogel in both proliferating and nonproliferating, mitomycin C (MMC) treated cells. The invasive response was less attenuated by the inhibition of proliferation in PDGF-BB stimulated cells compared with FGF-2 stimulated cells. We conclude that SMCs cultured in fibrin hydrogels have a more robust chemotactic response to PDGF-BB compared with FGF-2, and that the response to FGF-2 is more dependent on cell proliferation. Delivery of both growth factors together potentiates the chemotactic, but not mitogenic response to either growth factor alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.