Trial reportEuropean radiology2011
Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer-a per lesion validation study.
Trial report in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Apparent Diffusion Coefficient Can Predict Therapy Response of Hepatocellular Carcinoma to Transcatheter Arterial Chemoembolization.Digestive diseases (Basel, Switzerland) · 2022Pooled it
- Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors.BMC cancer · 2015Pooled it
- Interobserver agreement of semi-automated and manual measurements of functional MRI metrics of treatment response in hepatocellular carcinoma.European journal of radiology · 2014Trial
- Lymph nodes in MRI-based early-stage rectal cancer: can MRI accurately predict lymph node involvement?European radiology · 2026Article
- Masquerading Spleen: A Perplexing Case of Intrahepatic Splenosis Mimicking Hepatocellular Carcinoma.Cureus · 2024Article
- Multicenter Evaluation of a Weakly Supervised Deep Learning Model for Lymph Node Diagnosis in Rectal Cancer at MRI.Radiology. Artificial intelligence · 2024Article
- Article
- Lymph Nodes Evaluation in Rectal Cancer: Where Do We Stand and Future Perspective.Journal of clinical medicine · 2022Review
- Multi-parametric MRI (mpMRI) for treatment response assessment of radiation therapy.Medical physics · 2022Article
- Intra- and Interobserver Variability in Magnetic Resonance Imaging Measurements in Rectal Cancer Patients.Cancers · 2021Article
- Feasibility and reproducibility of T2 mapping and DWI for identifying malignant lymph nodes in rectal cancer.European radiology · 2021Article
- Accuracy of MRI for nodal restaging in rectal cancer: a retrospective study of 166 cases.Abdominal radiology (New York) · 2021Article
- Watch and wait approach in rectal cancer: Current controversies and future directions.World journal of gastroenterology · 2020Review
- Value of intra-tumor heterogeneity evaluated by diffusion-weighted MRI for predicting pathological stages and therapeutic responses to chemoradiotherapy in lower rectal cancer.Journal of Cancer · 2020Article
- Colorectal cancer: Parametric evaluation of morphological, functional and molecular tomographic imaging.World journal of gastroenterology · 2019Review
- [Rational staging and follow-up of colorectal cancer : Do guidelines provide further help?]Der Radiologe · 2019Review
- Diffusion-weighted imaging in rectal cancer: current applications and future perspectives.The British journal of radiology · 2019Review
- Response evaluation after neoadjuvant treatment for rectal cancer using modern MR imaging: a pictorial review.Insights into imaging · 2019Review
- Magnetic resonance imaging in locally advanced rectal cancer: quantitative evaluation of the complete response to neoadjuvant therapy.Polish journal of radiology · 2018Article
- How Should Imaging Direct/Orient Management of Rectal Cancer?Clinics in colon and rectal surgery · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the performance of diffusion-weighted MRI (DWI) in addition to T2-weighted (T2W) MRI for nodal restaging after chemoradiation in rectal cancer.
methodsThirty patients underwent chemoradiation followed by MRI (1.5 T) and surgery. Imaging consisted of T2W-MRI and DWI (b0, 500, 1000). On T2W-MRI, nodes were scored as benign/malignant by two independent readers (R1, R2). Mean apparent diffusion coefficient (ADC) was measured for each node. Diagnostic performance was compared for T2W-MRI, ADC and T2W+ADC, using a per lesion histological validation.
resultsADC was higher for the malignant nodes (1.43 ± 0.38 vs 1.19 ± 0.27 *10⁻³ mm²/s, p < 0.001). Area under the ROC curve/sensitivity/specificity were 0.88/65%/93% (R1) and 0.95/71%/91% (R2) using T2W-MRI; 0.66/53%/82% using ADC (mean of two readers); and 0.91/56%/98% (R1) and 0.96/56%/99% (R2) using T2W+ADC. There was no significant difference between T2W-MRI and T2W+ADC. Interobserver reproducibility was good for T2W-MRI (κ0.73) and ADC (intraclass correlation coefficient 0.77).
conclusionsAfter chemoradiation, ADC measurements may have potential for nodal characterisation, but DWI on its own is not reliable. Addition of DWI to T2W-MRI does not improve accuracy and T2W-MRI is already sufficiently accurate.
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