ArticlePediatric cardiology2010
Heterotaxy syndrome: defining contemporary disease trends.
Article in Pediatric cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Case Report: Laparoscopic appendectomy in a patient with congenital visceral heterotaxy and severe adhesions.Frontiers in surgery · 2025Article
- Heterotaxy Syndrome Diagnosed in an Adult.Ochsner journal · 2024Article
- Cardiac surgical outcomes of patients with heterotaxy syndrome.JTCVS open · 2023Article
- Article
- Fatal pneumococcal septicemia in a girl with visceral heterotaxy and polysplenia: a case report.Forensic science, medicine, and pathology · 2020Article
- Increased mortality, morbidities, and costs after heart transplantation in heterotaxy syndrome and other complex situs arrangements.The Journal of thoracic and cardiovascular surgery · 2019Article
- Successful Palliation via Kawashima Procedure of an Infant With Heterotaxy Syndrome and Left-Atrial Isomerism.Ochsner journal · 2018Article
- Comparing levocardia and dextrocardia in fetuses with heterotaxy syndrome: prenatal features, clinical significance and outcomes.BMC pregnancy and childbirth · 2017Article
- Pneumococcal vaccination and efficacy in patients with heterotaxy syndrome.Pediatric research · 2017Article
- Characteristics of Hospitalizations for the Glenn Procedure in Those With Isomerism Compared to Those Without.Pediatric cardiology · 2016Article
- Low immunoglobulin M memory B-cell percentage in patients with heterotaxy syndrome correlates with the risk of severe bacterial infection.Pediatric research · 2016Article
- Asplenia in children with congenital heart disease as a cause of poor outcome.Central-European journal of immunology · 2015Article
- Non-cardiac issues in patients with heterotaxy syndrome.Annals of pediatric cardiology · 2014Review
- Heterotaxy syndrome: impact of ventricular morphology on resource utilization.Pediatric cardiology · 2014Article
- A contemporary assessment of the risk for sudden cardiac death in patients with congenital heart disease.Pediatric cardiology · 2012Review
- Thoracic situs as an indicator of atrial appendage morphology: a postmortem study of 306 specimens with situs solitus in 250 and heterotaxy in 56 cases.Pediatric cardiology · 2011Article
- Genetic counseling in the adult with congenital heart disease: what is the role?Current cardiology reports · 2011Article
- Left atrial isomerism associated with aneurysmal enlargement of right atrial appendage: A case report with literature review.The Indian journal of radiology & imagingArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to define a population of visceral heterotaxy and to investigate the incidence of bacterial sepsis in the current era of universal pediatric pneumococcal immunization. Pediatric echocardiography and radiology databases, along with electronic medical records, were searched for patients followed-up since birth between 1999 and 2009 with either asplenia or polysplenia and cardiac anatomy consistent with heterotaxy syndrome. A total of 29 patients were identified. Seven patients (24%) had a total of 8 sepsis events, and 6 patients (86%) developed sepsis while taking appropriately prescribed antibiotic prophylaxis. Of the patients with sepsis, 5 had polysplenia and 2 had asplenia. Sixty-two percent of sepsis events were nosocomially acquired. No cases of pneumococcal sepsis occurred after the introduction of the conjugated pneumococcal vaccination to the pediatric vaccination schedule. Bacterial sepsis was associated with a 44% mortality rate. An unexpected finding in 3 patients with visceral heterotaxy, asplenia, and an interrupted inferior vena cava (IVC) as the only anomaly on echocardiography was associated intestinal malrotation. Children with visceral heterotaxy remain at significant risk of life-threatening bacterial infection. In addition, the finding of interrupted IVC on echocardiography should prompt screening for intestinal malrotation, even in the absence of additional structural heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.