ArticlePloS one2010
Consolidation of an olfactory memory trace in the olfactory bulb is required for learning-induced survival of adult-born neurons and long-term memory.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Abnormal white matter within brain structural networks is associated with high-impulse behaviour in codeine-containing cough syrup dependent users.European archives of psychiatry and clinical neuroscience · 2021Article
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Rapid online learning and robust recall in a neuromorphic olfactory circuit.Nature machine intelligence · 2020Article
- Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.Scientific reports · 2019Article
- Kinase activity in the olfactory bulb is required for odor memory consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer's Disease.Neurotoxicity research · 2016Review
- Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion.Neural regeneration research · 2015Article
- Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials.Radiation oncology journal · 2014Review
- The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Properties and mechanisms of olfactory learning and memory.Frontiers in behavioral neuroscience · 2014Review
- Context-driven activation of odor representations in the absence of olfactory stimuli in the olfactory bulb and piriform cortex.Frontiers in behavioral neuroscience · 2014Article
- Action of the noradrenergic system on adult-born cells is required for olfactory learning in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- On-Center/Inhibitory-Surround Decorrelation via Intraglomerular Inhibition in the Olfactory Bulb Glomerular Layer.Frontiers in integrative neuroscience · 2012Article
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- Neurogenesis drives stimulus decorrelation in a model of the olfactory bulb.PLoS computational biology · 2012Article
- Involvement of newborn neurons in olfactory associative learning? The operant or non-operant component of the task makes all the difference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Acquisition of an olfactory associative task triggers a regionalized down-regulation of adult born neuron cell death.Frontiers in neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has recently been proposed that adult-born neurons in the olfactory bulb, whose survival is modulated by learning, support long-term olfactory memory. However, the mechanism used to select which adult-born neurons following learning will participate in the long-term retention of olfactory information is unknown. We addressed this question by investigating the effect of bulbar consolidation of olfactory learning on memory and neurogenesis. METHODOLOGY/PRINCIPAL
findingsInitially, we used a behavioral ecological approach using adult mice to assess the impact of consolidation on neurogenesis. Using learning paradigms in which consolidation time was varied, we showed that a spaced (across days), but not a massed (within day), learning paradigm increased survival of adult-born neurons and allowed long-term retention of the task. Subsequently, we used a pharmacological approach to block consolidation in the olfactory bulb, consisting in intrabulbar infusion of the protein synthesis inhibitor anisomycin, and found impaired learning and no increase in neurogenesis, while basic olfactory processing and the basal rate of adult-born neuron survival remained unaffected. Taken together these data indicate that survival of adult-born neurons during learning depends on consolidation processes taking place in the olfactory bulb. CONCLUSION/SIGNIFICANCE: We can thus propose a model in which consolidation processes in the olfactory bulb determine both survival of adult-born neurons and long-term olfactory memory. The finding that adult-born neuron survival during olfactory learning is governed by consolidation in the olfactory bulb strongly argues in favor of a role for bulbar adult-born neurons in supporting olfactory memory.
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