ArticleNature structural & molecular biology2010
Structural basis for selective activation of ABA receptors.
Article in Nature structural & molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- An Engineered Abscisic Acid Receptor Enhances ABA Signaling and Improves Abiotic Stress Tolerance in Rice.Plant, cell & environment · 2026Article
- The genetic architecture of an allosteric hormone receptor.Nature communications · 2026Article
- ABA-independent PP2C-binding in PYLs traces to bacterial origins and persists in land plants.Nature communications · 2025Article
- Corepressor AtSDR4L and its paralog regulate hormonal and hypoxia responses in multiple Arabidopsis seed compartments.Plant physiology · 2025Article
- Stabilization of dimeric PYR/PYL/RCAR family members relieves abscisic acid-induced inhibition of seed germination.Nature communications · 2024Article
- Genome-wide analysis of the PYL-PP2C-SnRK2s family in the ABA signaling pathway of pitaya reveals its expression profiles under canker disease stress.BMC genomics · 2024Article
- An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity.Nature chemical biology · 2024Article
- Structure-guided engineering of a receptor-agonist pair for inducible activation of the ABA adaptive response to drought.Science advances · 2023Article
- Amino acid motifs for the identification of novel protein interactants.Computational and structural biotechnology journal · 2023Review
- Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds.Nature biotechnology · 2022Article
- A Modified Yeast Two-Hybrid Platform Enables Dynamic Control of Expression Intensities to Unmask Properties of Protein-Protein Interactions.ACS synthetic biology · 2022Article
- Genome-wide identification of ABA receptor PYL/RCAR gene family and their response to cold stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Article
- Potent ABA-independent activation of engineered PYL3.FEBS open bio · 2021Article
- Genome-wide analysis ofBioengineered · 2020Article
- Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Genome-Wide Identification of the ABA Receptors Genes and Their Response to Abiotic Stress in Apple.Plants (Basel, Switzerland) · 2020Article
- Evolution of Abscisic Acid Signaling Module and Its Perception.Frontiers in plant science · 2020Review
- Molecular Determinants Elucidate the Selectivity in Abscisic Acid Receptor and HAB1 Protein Interactions.Frontiers in chemistry · 2020Article
- Genome-wide identification and characterization of ABA receptor PYL/RCAR gene family reveals evolution and roles in drought stress in Nicotiana tabacum.BMC genomics · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
Changing environmental conditions and lessening fresh water supplies have sparked intense interest in understanding and manipulating abscisic acid (ABA) signaling, which controls adaptive responses to drought and other abiotic stressors. We recently discovered a selective ABA agonist, pyrabactin, and used it to discover its primary target PYR1, the founding member of the PYR/PYL family of soluble ABA receptors. To understand pyrabactin's selectivity, we have taken a combined structural, chemical and genetic approach. We show that subtle differences between receptor binding pockets control ligand orientation between productive and nonproductive modes. Nonproductive binding occurs without gate closure and prevents receptor activation. Observations in solution show that these orientations are in rapid equilibrium that can be shifted by mutations to control maximal agonist activity. Our results provide a robust framework for the design of new agonists and reveal a new mechanism for agonist selectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.