ArticleBehavioural pharmacology2010
Eating high-fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning.
Article in Behavioural pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Eating a ketogenic diet enhances sensitivity of rats to the effects of methamphetamine, but not dopamine DPharmacology, biochemistry, and behavior · 2025Article
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring.The international journal of neuropsychopharmacology · 2021Article
- Dietary supplementation with fish oil reverses high fat diet-induced enhanced sensitivity to the behavioral effects of quinpirole.Behavioural pharmacology · 2019Article
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole.Behavioural pharmacology · 2017Article
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats.Drug and alcohol dependence · 2016Article
- Animal models for addiction medicine: From vulnerable phenotypes to addicted individuals.Progress in brain research · 2016Review
- Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning.European journal of pharmacology · 2015Article
- Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice.Experimental and clinical psychopharmacology · 2015Article
- Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats.Behavioural pharmacology · 2015Article
- Eating high fat chow decreases dopamine clearance in adolescent and adult male rats but selectively enhances the locomotor stimulating effects of cocaine in adolescents.The international journal of neuropsychopharmacology · 2015Article
- Eating high fat chow and the behavioral effects of direct-acting and indirect-acting dopamine receptor agonists in female rats.Behavioural pharmacology · 2014Article
- Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition.European journal of pharmacology · 2014Article
- Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT(2A/2C) receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane.Behavioural pharmacology · 2014Article
- You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists.Neuropharmacology · 2012Review
- Drinking sucrose enhances quinpirole-induced yawning in rats.Behavioural pharmacology · 2011Article
- Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction.Behavioural pharmacology · 2011Article
- Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole.Psychopharmacology · 2011Article
- Obesogenic diets may differentially alter dopamine control of sucrose and fructose intake in rats.Physiology & behavior · 2011Article
- Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats.European journal of pharmacology · 2011Article
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Abstract
Discriminative stimulus effects of direct acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high-fat chow increases sensitivity to quinpirole-induced yawning, and this study examined whether eating high-fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high-fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose-response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free-feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high-fat chow is likely because of enhanced sensitivity at D3 receptors. Thus, eating high-fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse.
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