ArticleEukaryotic cell2010
The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Developmental dynamic transcriptomics reveals multiple effectors and transcription factors critical for Ditylenchus destructor parasitism.BMC biology · 2025Article
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
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- Bioprocess of Gibberellic Acid byJournal of fungi (Basel, Switzerland) · 2024Review
- Genome-Wide Identification and Functional Analysis of the bZIP Transcription Factor Family in Rice Bakanae Disease Pathogen,International journal of molecular sciences · 2022Article
- Recent advances in metabolic regulation and bioengineering of gibberellic acid biosynthesis in Fusarium fujikuroi.World journal of microbiology & biotechnology · 2022Review
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- FvatfA regulates growth, stress tolerance as well as mycotoxin and pigment productions in Fusarium verticillioides.Applied microbiology and biotechnology · 2020Article
- The Gibberellin ProducerFrontiers in bioengineering and biotechnology · 2020Review
- The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.FEMS microbiology letters · 2019Article
- Engineering of the Filamentous FungusFrontiers in microbiology · 2018Review
- Functional Analysis of the Nitrogen Metabolite Repression Regulator GeneFrontiers in microbiology · 2016Article
- Translating biosynthetic gene clusters into fungal armor and weaponry.Nature chemical biology · 2015Review
- Nitrogen regulation of fungal secondary metabolism in fungi.Frontiers in microbiology · 2014Review
- Transcriptome analysis of the filamentous fungus Aspergillus nidulans directed to the global identification of promoters.BMC genomics · 2013Article
- Light-dependent functions of the Fusarium fujikuroi CryD DASH cryptochrome in development and secondary metabolism.Applied and environmental microbiology · 2013Article
- A sensing role of the glutamine synthetase in the nitrogen regulation network in Fusarium fujikuroi.PloS one · 2013Article
- Article
- Article
- The chromatin code of fungal secondary metabolite gene clusters.Applied microbiology and biotechnology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Fusarium fujikuroi, bikaverin (BIK) biosynthesis is subject to repression by nitrogen. Unlike most genes subject to nitrogen metabolite repression, it has been shown that transcription of bik biosynthetic genes is not AreA dependent. Searching for additional transcription factors that may be involved in nitrogen regulation, we cloned and characterized the orthologue of Aspergillus nidulans meaB, which encodes a bZIP transcription factor. Two transcripts are derived from F. fujikuroi meaB: the large transcript (meaB(L)) predominates under nitrogen-sufficient conditions and the smaller transcript (meaB(S)) under nitrogen limitation, in an AreA-dependent manner. MeaB is specifically translocated to the nucleus under nitrogen-sufficient conditions in both F. fujikuroi and A. nidulans. Deletion of meaB resulted in partial upregulation of several nitrogen-regulated genes, but only in the ΔmeaB ΔareA double mutant were the bikaverin genes significantly upregulated in the presence of glutamine. These data demonstrate that MeaB and AreA coordinately mediate nitrogen metabolite repression and, importantly, that independently of AreA, MeaB can mediate nitrogen metabolite repression at specific loci in F. fujikuroi.
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