ArticleThe Journal of biological chemistry2010
Rad9 is required for B cell proliferation and immunoglobulin class switch recombination.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- The Trends in Global Gene Expression in Mouse Embryonic Stem Cells During Spaceflight.Frontiers in genetics · 2019Article
- Rad9a is required for spermatogonia differentiation in mice.Oncotarget · 2016Article
- The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks.Nucleic acids research · 2015Article
- ATAD5 deficiency decreases B cell division and Igh recombination.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Increased sensitivity of DNA damage response-deficient cells to stimulated microgravity-induced DNA lesions.PloS one · 2015Article
- Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation.BMC molecular biology · 2014Article
- The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1.Nucleic acids research · 2014Article
- Clamping down on mammalian meiosis.Cell cycle (Georgetown, Tex.) · 2013Article
- Contributions of Rad9 to tumorigenesis.Journal of cellular biochemistry · 2012Review
- Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.Protein & cell · 2011Article
- The role of RAD9 in tumorigenesis.Journal of molecular cell biology · 2011Review
- Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B cell maturation and B cell-mediated antibody response require programmed DNA modifications such as the V(D)J recombination, the immunoglobulin (Ig) class switch recombination, and the somatic hypermutation to generate functional Igs. Many protein factors involved in DNA damage repair have been shown to be critical for the maturation and activation of B cells. Rad9 plays an important role in both DNA repair and cell cycle checkpoint control. However, its role in Ig generation has not been reported. In this study, we generated a conditional knock-out mouse line in which Rad9 is deleted specifically in B cells and investigated the function of Rad9 in B cells. The Rad9(-/-) B cells isolated from the conditional knock-out mice displayed impaired growth response and enhanced DNA lesions. Impaired Ig production in response to immunization in Rad9(-/-) mice was also detected. In addition, the Ig class switch recombination is deficient in Rad9(-/-) B cells. Taken together, Rad9 plays dual roles in generating functional antibodies and in maintaining the integrity of the whole genome in B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.