SynthesisJournal of endodontics2010
Frequency of nonodontogenic pain after endodontic therapy: a systematic review and meta-analysis.
Synthesis in Journal of endodontics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- From tooth pain to trigeminal sensitization: translational models, experimental readouts, and mechanism-guided therapeutic opportunities in odontogenic and headache-related orofacial pain.The journal of headache and pain · 2026Review
- Does Anterior Disc Displacement with Reduction Affect Postoperative Pain Perception After Root Canal Therapy? A Prospective Comparative Clinical Study.Diagnostics (Basel, Switzerland) · 2026Article
- Exploratory investigation of pain threshold in the facial and cervical regions following dental implant surgery.Oral and maxillofacial surgery · 2026Article
- Are dentists aware of post-traumatic trigeminal neuropathic pain? A web-based epidemiological survey.Journal of oral & facial pain and headache · 2025Article
- Characteristics and impact of pain from root-filled teeth. A practice-based cross-sectional study comparing painful teeth with and without signs of inflammatory dental disease.Journal of oral & facial pain and headache · 2024Article
- Post-traumatic Trigeminal Neuropathy Associated With Endodontic Therapy: A Systematic Review.Cureus · 2022Review
- Outcomes reporting in systematic reviews on non-surgical root canal treatment: A scoping review for the development of a core outcome set.International endodontic journal · 2022Article
- Patients with persistent idiopathic dentoalveolar pain in dental practice.International endodontic journal · 2022Observational
- Outcomes of referrals from endodontic to orofacial pain specialists: A retrospective cohort study.Clinical and experimental dental research · 2022Article
- Bupivacaine for Root Canal Treatment - Practitioner Behaviors and Patient Perspectives: Survey Studies.Local and regional anesthesia · 2022Article
- Are glia targets for neuropathic orofacial pain therapy?Journal of the American Dental Association (1939) · 2021Article
- Dental pulp stem cells from human teeth with deep caries displayed an enhanced angiogenesis potentialJournal of dental sciences · 2021Article
- Aspects of Clinical Malpractice in Endodontics.European journal of dentistry · 2019Article
- Oral surgery II: Part 5. Chronic orofacial pain.British dental journal · 2017Article
- Orofacial pain - an update on diagnosis and management.British dental journal · 2017Article
- Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study.Stem cell research & therapy · 2017Article
- [Orofacial pain - Trigeminal neuralgia and posttraumatic trigeminal neuropathy: Common features and differences].Schmerz (Berlin, Germany) · 2016Review
- Article
- Decreased face primary motor cortex (face-M1) excitability induced by noxious stimulation of the rat molar tooth pulp is dependent on the functional integrity of face-M1 astrocytes.Experimental brain research · 2015Article
- Differential diagnoses for persistent pain after root canal treatment: a study in the National Dental Practice-based Research Network.Journal of endodontics · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionLittle is known about ill-defined pain that persists after endodontic procedures, including an estimate of the problem's magnitude. We conducted a systematic review of prospective studies that reported the frequency of nonodontogenic pain in patients who had undergone endodontic procedures.
methodsNonodontogenic pain was defined as dentoalveolar pain present for 6 months or more after endodontic treatment without evidence of dental pathology. Endodontic procedures reviewed were nonsurgical root canal treatment, retreatment, and surgical root canal treatment. Studies were searched in four databases electronically, complemented by hand searching. A summary estimate of nonodontogenic tooth pain frequency was derived using random-effects meta-analysis.
resultsOf 770 articles retrieved and reviewed, 10 met inclusion criteria, and nine had data on both odontogenic and nonodontogenic causes of pain. A total of 3,343 teeth were enrolled within the included studies and 1,125 had follow-up information regarding pain status. We identified 48 teeth with nonodontogenic pain and estimated a 3.4% (95% confidence interval, 1.4%-5.5%) frequency of occurrence. In nine articles containing data regarding both odontogenic and nonodontogenic causes of tooth pain, 56% (44/78) of all cases were thought to have a nonodontogenic cause.
conclusionsNonodontogenic pain is not an uncommon outcome after root canal therapy and may represent half of all cases of persistent tooth pain. These findings have implications for the diagnosis and treatment of painful teeth that were previously root canal treated because therapy directed at the tooth in question would not be expected to resolve nonodontogenic pain.
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