ReviewExperimental gerontology2011
dSir2 and longevity in Drosophila.
Review in Experimental gerontology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6-associated neurodegeneration.Disease models & mechanisms · 2025Article
- Extended lifespan in female Drosophila melanogaster through late-life calorie restriction.GeroScience · 2024Article
- SIRT1, resveratrol and aging.Frontiers in genetics · 2024Review
- Drosophila Sirtuin 6 mediates developmental diet-dependent programming of adult physiology and survival.Aging cell · 2022Article
- Pterostilbene Promotes Mean Lifespan in Both Male and FemaleOxidative medicine and cellular longevity · 2022Article
- Evolution, Chance, and Aging.Frontiers in genetics · 2021Review
- Aging mechanisms-A perspective mostly fromAdvanced genetics (Hoboken, N.J.) · 2020Article
- Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes.Current neurovascular research · 2020Review
- Article
- Sirtuins in Renal Health and Disease.Journal of the American Society of Nephrology : JASN · 2018Review
- Experimental Models for Aging and their Potential for Novel Drug Discovery.Current neuropharmacology · 2018Review
- The role of declining adaptive homeostasis in ageing.The Journal of physiology · 2017Review
- The effects of Rpd3 on fly metabolism, health, and longevity.Experimental gerontology · 2016Review
- Article
- Tea polyphenols ameliorate fat storage induced by high-fat diet inBiochemistry and biophysics reports · 2015Article
- RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity.Aging · 2015Article
- Role of SIRT1 in autoimmune demyelination and neurodegeneration.Immunologic research · 2015Review
- The controversial world of sirtuins.Drug discovery today. Technologies · 2014Review
- Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent.Experimental gerontology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The silent information regulator 2 (Sir2 or Sirtuin) family of proteins is highly conserved and has been implicated in the extension of longevity for several species. Mammalian Sirtuins have been shown to affect various aspects of physiology including metabolism, the stress response, cell survival, replicative senescence, inflammation, the circadian rhythm, neurodegeneration, and even cancer. Evidence in Drosophila implicates Sir2 in at least some of the beneficial effects of caloric restriction (CR). CR delays age-related pathology and extends life span in a wide variety of species. Here we will review the evidence linking Drosophila Sir2 (dSir2) to longevity regulation and the pathway associated with CR in Drosophila, as well as the effects of the Sir2 activator resveratrol and potential interactions between dSir2 and p53.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.