ArticleDevelopmental biology2010
Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Specification and Patterning ofJournal of developmental biology · 2018Review
- Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks.PLoS genetics · 2018Article
- Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene.G3 (Bethesda, Md.) · 2016Article
- Transcription factor Dlx3 induces aryl hydrocarbon receptor promoter activity.Biochemistry and biophysics reports · 2016Article
- A conserved genetic mechanism specifies deutocerebral appendage identity in insects and arachnids.Proceedings. Biological sciences · 2015Article
- Article
- Drosophila distal-less and Rotund bind a single enhancer ensuring reliable and robust bric-a-brac2 expression in distinct limb morphogenetic fields.PLoS genetics · 2013Article
- Differential activity of Drosophila Hox genes induces myosin expression and can maintain compartment boundaries.PloS one · 2013Article
- Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development.Developmental biology · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
It is currently thought that antennal target genes are activated in Drosophila by the combined action of Distal-less, homothorax, and extradenticle, and that the Hox gene Antennapedia prevents activation of antennal genes in the leg by repressing homothorax. To test these ideas, we analyze a 62bp enhancer from the antennal gene spineless that is specific for the third antennal segment. This enhancer is activated by a tripartite complex of Distal-less, Homothorax, and Extradenticle. Surprisingly, Antennapedia represses the enhancer directly, at least in part by competing with Distal-less for binding. We show that Antennapedia is required in the leg only within a proximal ring that coexpresses Distal-less, Homothorax and Extradenticle. We conclude that the function of Antennapedia in the leg is not to repress homothorax, as has been suggested, but to directly repress spineless and other antennal genes that would otherwise be activated within this ring.
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