ArticleMalaria journal2010
Arm-in-cage testing of natural human-derived mosquito repellents.
Article in Malaria journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 128 citations in OpenAlex.
- Molecular Recognition of Odorant-Binding Proteins WmagOBP39280 and WmagOBP42531 to Wohlfahrtia magnifica Pheromones and Bactrian Camel Volatiles.Archives of insect biochemistry and physiology · 2026Article
- A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones fromInternational journal of molecular sciences · 2026Article
- Exploring the associations between preen oil bacterial, chemical and proteomic profiles of passerines.Antonie van Leeuwenhoek · 2025Article
- Behavioral responses of Phlebotomus papatasi (Diptera: Psychodidae) to host-derived semiochemicals.Journal of medical entomology · 2025Article
- Differences in human skin volatiles between populations with high and low attraction to mosquitoes.Parasites & vectors · 2025Article
- Making scents of mosquito repellents.Trends in parasitology · 2025Review
- Menstrual Cycle Matters in Host Attractiveness to Mosquitoes and Topical Repellent Protection.Insects · 2025Article
- Promoting Circular Economy by Leveraging Annatto Byproducts fromFoods (Basel, Switzerland) · 2025Article
- A critical review of current laboratory methods used to evaluate mosquito repellents.Frontiers in insect science · 2024Review
- Combinatorial encoding of odors in the mosquito antennal lobe.Nature communications · 2023Article
- Repellent Screening of Selected Plant Essential Oils Against Dengue Fever Mosquitoes Using Behavior Bioassays.Neotropical entomology · 2023Article
- Soap application alters mosquito-host interactions.iScience · 2023Article
- Cyclic Acetals as Novel Long-Lasting Mosquito Repellents.Journal of agricultural and food chemistry · 2023Article
- Article
- Study of the Repellent Activity of 60 Essential Oils and Their Main Constituents againstInsects · 2022Article
- Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels.Cell · 2022Article
- Review
- Mosquito Olfactory Response Ensemble enables pattern discovery by curating a behavioral and electrophysiological response database.iScience · 2022Article
- Behavioural Responses of MaleInsects · 2022Article
- Attraction and Repellent Behaviors of Culicoides Biting Midges toward Cow Dung, Carbon Dioxide, and Essential Oils.The Korean journal of parasitology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundIndividual human subjects are differentially attractive to mosquitoes and other biting insects. Previous investigations have demonstrated that this can be attributed partly to enhanced production of natural repellent chemicals by those individuals that attract few mosquitoes in the laboratory. The most important compounds in this respect include three aldehydes, octanal, nonanal and decanal, and two ketones, 6-methyl-5-hepten-2-one and geranylacetone [(E)-6,10-dimethylundeca-5,9-dien-2-one]. In olfactometer trials, these compounds interfered with attraction of mosquitoes to a host and consequently show promise as novel mosquito repellents.
methodsTo test whether these chemicals could provide protection against mosquitoes, laboratory repellency trials were carried out to test the chemicals individually at different concentrations and in different mixtures and ratios with three major disease vectors: Anopheles gambiae, Culex quinquefasciatus and Aedes aegypti.
resultsUp to 100% repellency was achieved depending on the type of repellent compound tested, the concentration and the relative composition of the mixture. The greatest effect was observed by mixing together two compounds, 6-methyl-5-hepten-2-one and geranylacetone in a 1:1 ratio. This mixture exceeded the repellency of DEET when presented at low concentrations. The repellent effect of this mixture was maintained over several hours. Altering the ratio of these compounds significantly affected the behavioural response of the mosquitoes, providing evidence for the ability of mosquitoes to detect and respond to specific mixtures and ratios of natural repellent compounds that are associated with host location.
conclusionThe optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel repellents for personal protection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.