ReviewImmunological reviews2010
New insights into the enigma of immunoglobulin D.
Review in Immunological reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 129 citations in OpenAlex.
- Immunoglobulin heavy chain locus duplication in bats.Science advances · 2026Article
- Antibodies in plasma and blood cells of horses.Open veterinary journal · 2026Article
- Exploring the Role of B-Cell Biotherapy in Myasthenia Gravis from a Genetic Perspective: A Mendelian Randomization Study.Molecular neurobiology · 2025Article
- Anti-IgD nanobodies as novel tools for studying human IgD biology.Scientific reports · 2025Article
- Immune Cells as Mediators of Lipidome Influence on Osteoporosis: Evidence from a Mediation Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Immunoglobulins: Mechanistic Approaches in Moderation of Various Inflammatory and Anti-inflammatory Pathways.Current pharmaceutical biotechnology · 2025Review
- IgT and IgD dominance in the teleost central nervous system.Frontiers in immunology · 2025Article
- Immunoglobulin class-switch recombination: Mechanism, regulation, and related diseases.MedComm · 2024Review
- Ancestry-based differences in the immune phenotype are associated with lupus activity.JCI insight · 2023Article
- Crystal structures of the human IgD Fab reveal insights into CMolecular immunology · 2023Article
- Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation.Genomics, proteomics & bioinformatics · 2023Article
- High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?Clinical rheumatology · 2023Article
- The role of inflammatory mediators in the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome.Molecular biology reports · 2022Review
- Mucosal Overexpression of Thymic Stromal Lymphopoietin and Proinflammatory Cytokines in Patients With Autoimmune Atrophic Gastritis.Clinical and translational gastroenterology · 2022Article
- Article
- Rad52 mediates class-switch DNA recombination to IgD.Nature communications · 2022Article
- Immunoglobulins in teleosts.Immunogenetics · 2021Review
- Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems.Immune network · 2020Review
- Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA.Nature reviews. Immunology · 2020Review
- Development of a Monoclonal Antibody Specific to the IgM Heavy Chain of Bighead Catfish (Biomolecules · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Immunoglobulin D (IgD) has remained a mysterious antibody class for almost half a century. IgD was initially thought to be a recently evolved Ig isotype expressed only by some mammalian species, but recent discoveries in fishes and amphibians demonstrate that IgD was present in the ancestor of all jawed vertebrates and has important immunological functions. The structure of IgD has been very dynamic throughout evolution. Mammals can express IgD through alternative splicing and class switch recombination. Active cell-dependent and T-cell-independent IgM-to-IgD class switching takes place in a unique subset of human B cells from the upper aerodigestive mucosa, which provides a layer of mucosal protection by interacting with many pathogens and their virulence factors. Circulating IgD can bind to myeloid cells such as basophils and induce antimicrobial, inflammatory, and B-cell-stimulating factors upon cross-linking, which contributes to not only immune surveillance but also inflammation and tissue damage when this pathway is overactivated under pathological conditions. Recent research shows that IgD is an important immunomodulator that orchestrates an ancestral surveillance system at the interface between immunity and inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.