ReviewImmunological reviews2010
Functional diversity of stem and progenitor cells with B-lymphopoietic potential.
Review in Immunological reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- The role of trained immunity in sepsis.Frontiers in immunology · 2024Review
- Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer.Cancer research · 2022Review
- Toll-like receptor and cytokine expression throughout the bone marrow differs between patients with low- and high-risk myelodysplastic syndromes.Experimental hematology · 2022Article
- The role of inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models?Frontiers in immunology · 2022Review
- IRF8 Impacts Self-Renewal of Hematopoietic Stem Cells by Regulating TLR9 Signaling Pathway of Innate Immune Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes.Frontiers in immunology · 2020Review
- Necroinflammation emerges as a key regulator of hematopoiesis in health and disease.Cell death and differentiation · 2019Review
- Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment.Current stem cell reports · 2018Article
- Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging.Cell stem cell · 2018Article
- The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture.International journal of molecular sciences · 2018Review
- Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules.Toxins · 2017Review
- NK Cell Responses Redefine Immunological Memory.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms.Blood cancer journal · 2016Article
- The Role of Toll-Like Receptors in Hematopoietic Malignancies.Frontiers in immunology · 2016Review
- Cutting Edge: Hematopoietic Stem Cell Expansion and Common Lymphoid Progenitor Depletion Require Hematopoietic-Derived, Cell-Autonomous TLR4 in a Model of Chronic Endotoxin.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Controversial Role of Toll-like Receptor 4 in Adult Stem Cells.Stem cell reviews and reports · 2015Review
- Novel molecular mechanism for generating NK-cell fitness and memory.European journal of immunology · 2015Review
- The biology of innate lymphoid cells.Nature · 2015Review
- Early B lymphocyte development: Similarities and differences in human and mouse.World journal of stem cells · 2014Review
- The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells.Cell · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Technical advances have made it possible to separate hematopoietic tissues such as the bone marrow into ever smaller populations, complicating our understanding of immune system replenishment. Patterns of surface marker expression and transcription profiles as well as results obtained with reporter mice suggest that lymphopoietic cells are not closely synchronized, and there is considerable cell to cell variation. Loss of differentiation options is gradual, and ultimate fate can be established at different stages of lineage progression. For example, individual hematopoietic stem cells can be biased such that some are very poor sources of lymphocytes as contrasted to ones with balanced outputs. Still other hematopoietic stem cells are effective at generating B and T cells but are defective with respect to expansion and difficult to distinguish from early lymphoid progenitors. That diversity carries forward to later events, and similar appearing cells in the immune system can arise from alternate differentiation pathways. In fact, new categories of lymphoid progenitors are still being discovered. Heterogeneity provides adaptability as hematopoiesis can be dramatically altered during infections, influencing numbers and types of cells that are produced.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.