Evidence map›Paper›PMID 20726859›Full record

ReviewCancer science2010

The microRNA pathway and cancer.

Pieter Bas Kwak, Shintaro Iwasaki, Yukihide Tomari

Open access · greenAbstract readReview
In one paragraph

Review in Cancer science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 4 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 241 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Review
  9. Next-Cell Hypothesis: Mechanism of Obesity-Associated Carcinogenesis.Advances in experimental medicine and biology · 2024
    Review
  10. Impacts ofBiomedicines · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Sequence Requirements for miR-424-5p Regulating and Function in Cancers.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Pieter Bas KwakInstitute of Molecular and Cellular Biosciences Department of Medical Genome Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Shintaro Iwasaki
Yukihide Tomari
Division of Molecular & Cellular Biosciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are ∼22nt long, non-coding RNAs that guide post-transcriptional gene silencing of their target genes and regulate diverse biological processes including cancer. miRNAs do not act alone, but require assembly into RNA-induced silencing complex (RISC). In this review, we summarize how miRNAs are produced, assembled into RISC, and regulate target mRNAs, and discuss how the miRNA pathway is involved in cancer.

Indexed as

RNA InterferenceSignal TransductionAnimalsGene Expression Regulation, NeoplasticHumansMicroRNAsModels, GeneticNeoplasmsRNA-Induced Silencing ComplexRNA, MessengerMicroRNAsRNA-Induced Silencing ComplexRNA, Messenger

Identifiers

PMID20726859
PMCPMC11159795
OpenAlexW2026936876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.