GuidelineJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2010
Best practice guide for the treatment of nightmare disorder in adults.
Guideline in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 90 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD
Treatment of Nightmares in Psychiatric Inpatients With Imagery Rehearsal Therapy: A Randomized Controlled Trial
Who cites it
90 citing papers in PubMed, 6 syntheses or guidelines pooled it, 328 citations in OpenAlex.
- The Effects of Pharmacological Treatment of Nightmares: A Systematic Literature Review and Meta-Analysis of Placebo-Controlled, Randomized Clinical Trials.International journal of environmental research and public health · 2022Pooled it
- The effects of prazosin on sleep disturbances in post-traumatic stress disorder: a systematic review and meta-analysis.Sleep medicine · 2020Pooled it
- Position Paper for the Treatment of Nightmare Disorder in Adults: An American Academy of Sleep Medicine Position Paper.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Guideline
- Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Comparative meta-analysis of prazosin and imagery rehearsal therapy for nightmare frequency, sleep quality, and posttraumatic stress.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Treatment of nightmares with prazosin: a systematic review.Mayo Clinic proceedings · 2012Pooled it
- Transdiagnostic cognitive behavioral therapy for nightmares and parasomnias.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- A randomized sham-controlled clinical trial of a novel wearable intervention for trauma-related nightmares in military veterans.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Cognitive Behavioural Therapy for Nightmares for Patients with Persecutory Delusions (Nites): An Assessor-Blind, Pilot Randomized Controlled Trial.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Trial
- Comorbid sleep disorders and suicide risk among children and adolescents with bipolar disorder.Journal of psychiatric research · 2017Trial
- Treatment of sleep disturbances in trauma-affected refugees: Study protocol for a randomised controlled trial.Trials · 2017Trial
- Efficacy of a behavioral self-help treatment with or without therapist guidance for co-morbid and primary insomnia--a randomized controlled trial.BMC psychiatry · 2012Trial
- Article
- Investigation of the "Not Better Explained" Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review.Journal of sleep research · 2026Review
- Differential Risks of Dementia, Depression, and Injury Among Common α-Blockers, with Tamsulosin as the Reference Drug: A Real-World Cohort Study in Men with Lower Urinary Tract Symptoms.Journal of clinical medicine · 2025Article
- Successful Treatment of Secondary Hypersomnia Due to Complex Post-Traumatic Stress Disorder with Eye Movement Desensitization and Reprocessing: A Case Report.Clocks & sleep · 2025Article
- Stepped care and digital intervention service model design in the multidisciplinary sleep service.Internet interventions · 2025Article
- Understanding and Treating Nightmares: A Comprehensive Review of Psychosocial Strategies for Adults and Children.Cureus · 2024Review
- Brief Psychoeducational and Cognitive Therapy for Nightmare Disorder (BPCT-ND).Sleep science (Sao Paulo, Brazil) · 2024Article
- A Retrospective Pilot Study of Imagery Rehearsal Therapy Enhanced with Narrative Therapy Principles for the Treatment of Nightmares in US Military Veterans.Sleep science (Sao Paulo, Brazil) · 2023Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
14 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prazosin is recommended for treatment of Posttraumatic Stress Disorder (PTSD)-associated nightmares. Level A. Image Rehearsal Therapy (IRT) is recommended for treatment of nightmare disorder. Level A. Systematic Desensitization and Progressive Deep Muscle Relaxation training are suggested for treatment of idiopathic nightmares. Level B. Venlafaxine is not suggested for treatment of PTSD-associated nightmares. Level B. Clonidine may be considered for treatment of PTSD-associated nightmares. Level C. The following medications may be considered for treatment of PTSD-associated nightmares, but the data are low grade and sparse: trazodone, atypical antipsychotic medications, topiramate, low dose cortisol, fluvoxamine, triazolam and nitrazepam, phenelzine, gabapentin, cyproheptadine, and tricyclic antidepressants. Nefazodone is not recommended as first line therapy for nightmare disorder because of the increased risk of hepatotoxicity. Level C. The following behavioral therapies may be considered for treatment of PTSD-associated nightmares based on low-grade evidence: Exposure, Relaxation, and Rescripting Therapy (ERRT); Sleep Dynamic Therapy; Hypnosis; Eye-Movement Desensitization and Reprocessing (EMDR); and the Testimony Method. Level C. The following behavioral therapies may be considered for treatment of nightmare disorder based on low-grade evidence: Lucid Dreaming Therapy and Self-Exposure Therapy. Level C No recommendation is made regarding clonazepam and individual psychotherapy because of sparse data.
Indexed as
Identifiers
20726290PMC2919672W2119624339What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.