Evidence map›Paper›PMID 20726278›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2010

The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia.

Andrew D Krystal, Gary K Zammit, James K Wyatt, Stuart F Quan, Jack D Edinger, David P White, Richard P Chiacchierini, Atul Malhotra

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. A possible method to predict response to non-pharmacological insomnia therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2011
    Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Vestibular Stimulation for Stress Management in Students.Journal of clinical and diagnostic research : JCDR · 2016
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Andrew D KrystalDuke University School of Medicine, Durham, NC 27710, USA. kryst001@mc.duke.edu
Gary K Zammit
James K Wyatt
Stuart F Quan
Jack D Edinger
David P White
Richard P Chiacchierini
Atul Malhotra
Brigham and Women's Hospital · USClinilabs (United States) · USDuke University · USMDS Associates (United States) · USRush University · USUnited States Department of Veterans Affairs · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesTo determine if vestibular stimulation is an effective therapy for transient insomnia in a sleep phase advance model.

designMulti-site, double-blind, randomized, parallel-group, sham-controlled trial

settingThis study was carried out at 6 sites in the United States.

participants198 healthy normal sleepers.

interventionsBilateral electrical stimulation of the vestibular apparatus of the inner ear via electrodes on the skin of the mastoid process at a frequency of 0.5 Hz vs. sham stimulation.

resultsWe did not find a significant effect of treatment on our primary outcome variable, latency to persistent sleep onset (LPS). However, our planned analysis identified that the mean latency to sleep onset on the multiple sleep latency test was a significant covariate. This led us to carry out post hoc analyses, which showed a significant effect of treatment on LPS in those subjects with a mean MSLT sleep onset latency > or = 14 minutes.

conclusionsVestibular stimulation did not have a therapeutic effect in a model of transient insomnia in the overall population studied. However, this study provides preliminary evidence that vestibular stimulation may shorten sleep onset latency compared with sham therapy in the subset of subjects with mean MSLT sleep onset latency > or = 14 minutes.

Indexed as

Sleep Phase ChronotherapyAdultCase-Control StudiesDouble-Blind MethodFemaleHumansKinesthesisMaleMiddle AgedPolysomnographySleep Initiation and Maintenance DisordersTranscutaneous Electric Nerve StimulationVestibule, Labyrinth

Identifiers

PMID20726278
PMCPMC2919660
OpenAlexW1518416061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.