ReviewImmunologic research2010
Translating insights from persistent LCMV infection into anti-HIV immunity.
Review in Immunologic research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Immune checkpoint landscape in CD4⁺ T cells stratifies HIV-infected individuals by clinical progression.Immunologic research · 2026Article
- Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C.Journal for immunotherapy of cancer · 2024Article
- Persistent lentivirus infection induces early myeloid suppressor cells expansion to subvert protective memory CD8 T cell responseEBioMedicine · 2020Article
- Systems analysis reveals complex biological processes during virus infection fate decisions.Genome research · 2019Article
- Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming.AIDS research and human retroviruses · 2017Article
- Impaired Subset Progression and Polyfunctionality of T Cells in Mice Exposed to Methamphetamine during Chronic LCMV Infection.PloS one · 2016Article
- Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity.Virology · 2015Article
- Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.PLoS pathogens · 2015Article
- Networking at the level of host immunity: immune cell interactions during persistent viral infections.Cell host & microbe · 2013Review
- Blockade of chronic type I interferon signaling to control persistent LCMV infection.Science (New York, N.Y.) · 2013Article
- CD8+ T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor.Immunological investigations · 2013Article
- Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.The Journal of experimental medicine · 2012Article
- Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.Journal of virology · 2012Article
- Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection.Cell host & microbe · 2012Article
- IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.Immunology and cell biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Human immunodeficiency virus (HIV) is a major global health concern with more than 30 million individuals currently infected worldwide. To date, attempts to stimulate protective immunity to viral components of HIV have been unsuccessful in preventing or clearing infection. Lymphocytic choriomeningitis virus (LCMV) is an established murine model of persistent viral infection that has been instrumental in illuminating several critical aspects of antiviral immunity. Although virologically the course of LCMV infection differs significantly from HIV, the immune responses and regulatory mechanisms elicited by these two viruses are markedly similar. In this review we discuss important recent findings in the LCMV model, highlighting the role of host-derived proteins in shaping immune responses to persistent infections, and explore the therapeutic potential of manipulating these pathways to enhance HIV vaccination strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.