Evidence map›Paper›PMID 20725786›Full record

ReviewDigestive diseases and sciences2010

Gastrointestinal stromal tumors (GISTs): an updated experience.

Anastasios Machairas, Eva Karamitopoulou, Dimitrios Tsapralis, Theodore Karatzas, Nickolas Machairas, Evangelos P Misiakos

Abstract readReview
PubMed Publisher
In one paragraph

Review in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anastasios Machairas3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, 1 Rimini Street, Chaidari-Athens 12462, Greece.
Eva Karamitopoulou
Dimitrios Tsapralis
Theodore Karatzas
Nickolas Machairas
Evangelos P Misiakos
National and Kapodistrian University of Athens · GRUniversity General Hospital Attikon · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors of the digestive tract characterized by c-KIT mutations. This is a comprehensive review of the current data of the literature on the various aspects of the diagnosis and treatment of these tumors.

methodsThe stomach is the most commonly involved site for these tumors in the digestive tract. Computed tomography and endoscopy can usually establish the diagnosis. The study of certain specific immunohistochemical markers may contribute to better characterization of these tumors.

resultsSurgical resection of GISTs has been the most effective therapy. In addition, targeted therapy with tyrosine kinase inhibitors may reduce the development of recurrence or decrease the disease progression in patients with metastatic disease.

conclusionsThe introduction of tyrosine kinase inhibitors has resulted in significant improvement in the overall prognosis of these patients. Furthermore, preoperative imatinib can decrease tumor volume and is associated with complete surgical resection in locally advanced primary GISTs.

Indexed as

Antineoplastic AgentsBenzamidesBiomarkers, TumorDiagnosis, DifferentialDisease ProgressionEndoscopy, GastrointestinalGastrointestinal Stromal TumorsHumansImatinib MesylateImmunohistochemistryNeoplasm Recurrence, LocalPiperazinesProto-Oncogene Proteins c-kitPyrimidinesReceptor, Platelet-Derived Growth Factor alphaAntineoplastic AgentsBenzamidesBiomarkers, TumorImatinib MesylatePiperazinesProto-Oncogene Proteins c-kitPyrimidinesReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID20725786
OpenAlexW2000440450

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.