ArticleCellular and molecular life sciences : CMLS2011
cAMP initiates early phase neuron-like morphology changes and late phase neural differentiation in mesenchymal stem cells.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- HO-1 Nuclear Interactome Implications in Neuroendocrine Transdifferentiation in Prostate Cancer.International journal of molecular sciences · 2026Article
- NRSF regulation of OPRM1 through histone acetylation.Clinical epigenetics · 2026Article
- Immunomodulatory and Regenerative Functions of MSC-Derived Exosomes in Bone Repair.Bioengineering (Basel, Switzerland) · 2025Review
- Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.Reproductive biology and endocrinology : RB&E · 2024Article
- Carbachol, along with calcium, indicates new strategy in neural differentiation of human adipose tissue-derived mesenchymal stem cellsRegenerative therapy · 2023Article
- Soft surfaces induce neural differentiation via the neuron restrictive silencer factor.Biochemical engineering journal · 2022Article
- Neural Differentiation of Human-Induced Pluripotent Stem Cells (hiPSc) on Surface-Modified Nanofibrous Scaffolds Coated with Platelet-Rich Plasma.Neurochemical research · 2022Article
- Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD.Biochimica et biophysica acta. Molecular cell research · 2020Article
- Forskolin and IBMX Induce Neural Transdifferentiation of MSCs Through Downregulation of the NRSF.Scientific reports · 2019Article
- Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells.International journal of molecular sciences · 2018Article
- An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells.Stem cell reviews and reports · 2016Review
- Rapid Induction of Neural Differentiation in Human Umbilical Cord Matrix Mesenchymal Stem Cells by cAMP-elevating Agents.International journal of molecular and cellular medicine · 2016Article
- Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing.The Journal of biological chemistry · 2015Article
- CREB modulates calcium signaling in cAMP-induced bone marrow stromal cells (BMSCs).Cell calcium · 2014Article
- Different forms of tenascin-C with tenascin-R regulate neural differentiation in bone marrow-derived human mesenchymal stem cells.Tissue engineering. Part A · 2014Article
- Comparison of different protocols for neural differentiation of human induced pluripotent stem cells.Molecular biology reports · 2014Article
- IPAF inflammasome is involved in interleukin-1β production from astrocytes, induced by palmitate; implications for Alzheimer's Disease.Neurobiology of aging · 2014Article
- Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes.Experimental neurology · 2013Article
- Concise review: adult mesenchymal stem cells, adult neural crest stem cells, and therapy of neurological pathologies: a state of play.Stem cells translational medicine · 2013Review
- Quantitative, solution-phase profiling of multiple transcription factors in parallel.Analytical and bioanalytical chemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The intracellular second messenger cAMP is frequently used in induction media to induce mesenchymal stem cells (MSCs) into neural lineage cells. To date, an understanding of the role cAMP exerts on MSCs and whether cAMP can induce MSCs into functional neurons is still lacking. We found cAMP initiated neuron-like morphology changes early and neural differentiation much later. The early phase changes in morphology were due to cell shrinkage, which subsequently rendered some cells apoptotic. While the morphology changes occurred prior to the expression of neural markers, it is not required for neural marker expression and the two processes are differentially regulated downstream of cAMP-activated protein kinase A. cAMP enabled MSCs to gain neural marker expressions with neuronal function, such as, calcium rise in response to neuronal activators, dopamine, glutamate, and potassium chloride. However, only some of the cells induced by cAMP responded to the three neuronal activators and further lack the neuronal morphology, suggesting that although cAMP is able to direct MSCs towards neural differentiation, they do not achieve terminal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.